Anti-C1r antibody [EPR14915]

Target data

Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed : 17996945, PubMed : 19473974, PubMed : 29449492). C1R catalyzes the first enzymatic step in the classical complement pathway : it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens (PubMed : 29449492, PubMed : 34155115). Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R (PubMed : 11445589, PubMed : 11673533, PubMed : 17996945, PubMed : 20178990, PubMed : 6254570, PubMed : 6271784). Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway (PubMed : 11445589, PubMed : 11673533, PubMed : 6271784). It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces (PubMed : 28104818, PubMed : 29311313, PubMed : 29449492).