AB81707

Anti-C1s antibody [M81]

Name: Anti-C1s antibody [M81] (ab81707) | Abcam
Brand: Abcam Limited
SKU: AB81707
Price: 515 USD
Availability: InStock
Rating: 4 (1 reviews)

(1 Review)

(1 Publication)

Mouse Monoclonal C1S antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Complement C1s subcomponent, C1 esterase, Complement component 1 subcomponent s, C1S

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1s antibody [M81] (AB81707)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1s antibody [M81] (AB81707)

ab81707, at a dilution of 1/50, staining paraffin embedded human liver melanoma cells by Immunohistochemistry. Insert is isotype control.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

M81

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Epitope

ab81707 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). The epitope recognized by ab81707 is domain IV and/or V of the gamma domain of activated C1s.

Specificity

ab81707 reacts around the binding site of C1s and reacts with both active and inactive C1s.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification notes

ab81707 is a purified, 0.2 µm filtered solution.

Storage buffer

Constituents: PBS, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Cleaves also IGFBP5 and thereby inhibits the trophic effects of IGF1.

See full target information C1S

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology (Baltimore, Md. : 1950) 142:2743-50 PubMed2522968

1989

Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain.

Applications

Unspecified application

Species

Unspecified reactive species

M Matsumoto,K Nagaki,H Kitamura,S Kuramitsu,S Nagasawa,T Seya

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