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AB188870

Anti-C2orf69 antibody [EPR13713]

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(2 Publications)

Rabbit Recombinant Monoclonal C2orf69 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

Mitochondrial protein C2orf69, C2orf69

1 Images
Western blot - Anti-C2orf69 antibody [EPR13713] (AB188870)
  • WB

Supplier Data

Western blot - Anti-C2orf69 antibody [EPR13713] (AB188870)

All lanes:

Western blot - Anti-C2orf69 antibody [EPR13713] (ab188870) at 1/1000 dilution

Lane 1:

Human stomach lysate at 20 µg

Lane 2:

U87-MG lysate at 20 µg

Lane 3:

HeLa lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Predicted band size: 43 kDa

false

  • Carrier free

    Anti-C2orf69 antibody [EPR13713] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13713

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C2orf69 also known as Chromosome 2 open reading frame 69 is a protein involved in specific cellular functions though the mechanical details remain not completely understood. The molecular mass of C2orf69 is approximately 46 kDa. It shows expression in multiple human tissues with notable presence in the brain and liver. This suggests its involvement in diverse biological processes.
Biological function summary

The C2orf69 protein appears implicated in cellular metabolic pathways contributing to energy production and cellular homeostasis. It potentially integrates into larger multi-protein complexes assisting in the regulation of metabolic flow. Its role in such processes emphasizes its importance in normal cell function and growth.

Pathways

C2orf69 interacts within energy metabolism and mitochondrial function pathways. It may interact with proteins important to these pathways such as those involved in respiratory chain and ATP synthesis. Understanding these interactions helps in deciphering C2orf69’s contribution to cellular metabolism and might provide insights into broader biological mechanisms.

C2orf69 associates with mitochondrial dysfunction and metabolic disorders like Leigh Syndrome and other neurodegenerative diseases. These conditions often involve disruptions in proteins such as NDUFS1 or other complex I components. Connections of C2orf69 with these proteins and diseases highlight potential targets for therapeutic intervention and warrant further investigation into its exact pathological role.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in the respiratory chain.
See full target information C2orf69
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 131: PubMed33945503

2021

C2orf69 mutations disrupt mitochondrial function and cause a multisystem human disorder with recurring autoinflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Eva Lausberg,Sebastian Gießelmann,Joseph P Dewulf,Elsa Wiame,Anja Holz,Ramona Salvarinova,Clara D van Karnebeek,Patricia Klemm,Kim Ohl,Michael Mull,Till Braunschweig,Joachim Weis,Clemens J Sommer,Stephanie Demuth,Claudia Haase,Claudia Stollbrink-Peschgens,François-Guillaume Debray,Cecile Libioulle,Daniela Choukair,Prasad T Oommen,Arndt Borkhardt,Harald Surowy,Dagmar Wieczorek,Norbert Wagner,Robert Meyer,Thomas Eggermann,Matthias Begemann,Emile Van Schaftingen,Martin Häusler,Klaus Tenbrock,Lambert van den Heuvel,Miriam Elbracht,Ingo Kurth,Florian Kraft

Bone research 6:32 PubMed30455992

2018

NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Ye,Feng Lou,Fanyuan Yu,Demao Zhang,Chenglin Wang,Fanzi Wu,Xin Li,Yilin Ping,Xiao Yang,Jing Yang,Dian Chen,Bo Gao,Dingming Huang,Peng Liu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com