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BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Mouse Monoclonal C3 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.
IgG1
Mouse
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA
Liquid
Monoclonal
WB | |
---|---|
Human | Expected |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.C3-beta-cActs as a chemoattractant for neutrophils in chronic inflammation.Acylation stimulating proteinadipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750).
Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, C3
Mouse Monoclonal C3 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.
Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, C3
IgG1
Mouse
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA
Liquid
Monoclonal
2991
Affinity purification Protein G
ab11873 reacts with a neo-epitope (des-Arg) on C3a that is formed when C3 is cleaved into C3a and C3b. ab11873 recognizes C3a and C3a des arg only.
It has the most affinity with C3a des arg and least affinity with C3a. The des arg variant has an about 5x higher affinity than C3a.
The antibody does not recognize C3b or full C3, as it recognizes a neo-epitope that is not available on C3.
0.2 µm filtered
Blue Ice
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
C3a serves as an essential inflammatory agent and is part of the complement system an important component of the innate immune response. It contributes to the defense against pathogens by promoting chemotaxis degranulation and the release of histamine. C3a desArg a derivative of C3a generated by the removal of the C-terminal arginine residue has reduced inflammatory activity. The activity of C3a and its link to inflammation highlights its importance in maintaining immune homeostasis and responding to infectious threats.
C3a also known as C3a des Arg or C3a full form is a small peptide anaphylatoxin derived from the complement component C3. It plays an important mechanical role in the immune system by acting as a potent mediator of inflammation. C3a weighs approximately 9 kDa. It expresses primarily on the surface of immune cells such as mast cells and basophils. The function of C3a involves the binding to the C3a receptor (C3aR) triggering a series of immune responses.
C3a plays an important role in the complement activation cascade particularly the classical and alternative pathways. This involvement highlights its relationship with proteins such as C3b and C5 which are critical in the opsonization and membrane attack complex formation. C3a's role in these pathways accentuates its importance in modulating inflammation and immune response.
Abnormalities in C3a regulation have notable implications. C3a is associated with various inflammatory and autoimmune diseases like asthma and rheumatoid arthritis. In asthma C3a interacts with other complement proteins such as C5a to exacerbate inflammation in the airways. Dysregulation of C3a and its conversion to C3a desArg may further contribute to pathologies implicating its potential as a therapeutic target in managing inflammatory diseases.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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