AB140788

Anti-C3a R antibody

Name: Anti-C3a R antibody (ab140788) | Abcam
Brand: Abcam Limited
SKU: AB140788

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(2 Publications)

Rabbit Polyclonal C3a R antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human C3AR1.

View Alternative Names

AZ3B, C3R1, HNFAG09, C3AR1, C3a anaphylatoxin chemotactic receptor, C3AR, C3a-R

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C3a R antibody (AB140788)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C3a R antibody (AB140788)

Immunohistochemical analysis of Human lung tissue labelling C3a R with ab140788 at 17.3 μg/ml.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C3a R antibody (AB140788)

Immunohistochemical analysis of Human small intestine tissue labelling C3a R with ab140788 at 17.3 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human C3AR1. The exact immunogen used to generate this antibody is proprietary information.

Q16581

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except ADRA1A (40%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "17.3 µg/mL", "IHCP-species-notes": "<p></p>" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The C3a receptor also known as C3aR or C3aR1 is a critical component of the immune system. It functions by binding to the C3a peptide a product of the complement cascade. This binding triggers a variety of immune responses. C3aR is a surface receptor widely expressed on immune cells such as macrophages mast cells and neutrophils. The molecular weight of the C3a receptor is approximately 55 kDa. It can be found principally in tissues involved in immunity like the spleen lungs and liver.

Biological function summary

The C3a receptor plays an important role in the immune response by mediating inflammatory reactions. It is not part of a larger complex like some receptors functioning instead through protein-protein interactions. Upon activation by binding with the C3a peptide the receptor can promote the release of histamine cytokines and other inflammatory mediators. This action helps regulate the body's defense against pathogens and contributes to the elimination of foreign materials from the body.

Pathways

The C3a receptor is involved in the complement pathway and immune response pathways. It interacts with several proteins within these pathways including C3a protein itself and other complement components. By engaging in these pathways C3aR significantly influences cellular responses and activities. For example its activation can lead to the alteration of immune cell behavior enhancing phagocytosis and increasing cell migration to sites of infection or injury.

The C3a receptor has been implicated in asthma and rheumatoid arthritis. In asthma C3aR activation can lead to overactive immune responses causing increased bronchoconstriction and airway hyperresponsiveness. Its involvement in rheumatoid arthritis relates to its ability to modulate inflammation exacerbating joint damage and discomfort. The receptor's activity in these conditions can also connect it to other proteins such as specific inflammatory cytokines which contribute to the pathological processes seen in these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production (PubMed : 12871936, PubMed : 37852260, PubMed : 8702752). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 37852260). C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed : 37852260).

See full target information C3AR1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Clinical and experimental medicine 24:139 PubMed38951265

2024

Complement C3a/C3aR and C5a/C5aR deposits accelerate the progression of advanced IgA nephropathy to end-stage renal disease.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Wang,Shunlai Shang,Shimin Jiang,Guming Zou,Hongmei Gao,Wenge Li

The Journal of clinical investigation 128:5235-5250 PubMed30204129

2018

HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk.

Applications

Unspecified application

Species

Unspecified reactive species

Yingying Wang,Xiaoling Weng,Luoyang Wang,Mingang Hao,Yue Li,Lidan Hou,Yu Liang,Tianqi Wu,Mengfei Yao,Guowen Lin,Yiwei Jiang,Guohui Fu,Zhaoyuan Hou,Xiangjun Meng,Jinsong Lu,Jianhua Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-C3a R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C3a R antibody (AB140788)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C3a R antibody (AB140788)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise