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AB59554

Anti-C3a R antibody [hC3aRZ1]

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Mouse Monoclonal C3a R antibody. Suitable for Flow Cyt, IHC-Fr and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human C3AR1.

View Alternative Names

AZ3B, C3R1, HNFAG09, C3AR1, C3a anaphylatoxin chemotactic receptor, C3AR, C3a-R

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

hC3aRZ1

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, IHC-Fr

applications

Immunogen

Recombinant Full Length Protein corresponding to Human C3AR1.

Q16581

Specificity

This antibody recognizes the receptor for human complement component C3a (C3aR) (55kD)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "1/10 - 1/20", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p><p>Use 10μl of the sugested working dilution to label 1x10<sup>6</sup> cells in 100μl.</p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from tissue culture supernatant
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The C3a receptor also known as C3aR or C3aR1 is a critical component of the immune system. It functions by binding to the C3a peptide a product of the complement cascade. This binding triggers a variety of immune responses. C3aR is a surface receptor widely expressed on immune cells such as macrophages mast cells and neutrophils. The molecular weight of the C3a receptor is approximately 55 kDa. It can be found principally in tissues involved in immunity like the spleen lungs and liver.
Biological function summary

The C3a receptor plays an important role in the immune response by mediating inflammatory reactions. It is not part of a larger complex like some receptors functioning instead through protein-protein interactions. Upon activation by binding with the C3a peptide the receptor can promote the release of histamine cytokines and other inflammatory mediators. This action helps regulate the body's defense against pathogens and contributes to the elimination of foreign materials from the body.

Pathways

The C3a receptor is involved in the complement pathway and immune response pathways. It interacts with several proteins within these pathways including C3a protein itself and other complement components. By engaging in these pathways C3aR significantly influences cellular responses and activities. For example its activation can lead to the alteration of immune cell behavior enhancing phagocytosis and increasing cell migration to sites of infection or injury.

The C3a receptor has been implicated in asthma and rheumatoid arthritis. In asthma C3aR activation can lead to overactive immune responses causing increased bronchoconstriction and airway hyperresponsiveness. Its involvement in rheumatoid arthritis relates to its ability to modulate inflammation exacerbating joint damage and discomfort. The receptor's activity in these conditions can also connect it to other proteins such as specific inflammatory cytokines which contribute to the pathological processes seen in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
See full target information C3AR1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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