AB187278

Anti-C4d antibody [C4D204]

Name: Anti-C4d antibody [C4D204] (ab187278) | Abcam
Brand: Abcam Limited
SKU: AB187278
Price: 520 USD
Availability: InStock

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(1 Publication)

Mouse Monoclonal C4A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human C4A.

View Alternative Names

CO4, CPAMD2, Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C4d antibody [C4D204] (AB187278)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C4d antibody [C4D204] (AB187278)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded kidney transplant tissue labeling C4d with ab187278 at 1/100 dilution for 30 minutes at RT.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C4d antibody [C4D204] (AB187278)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded kidney transplant tissue labeling C4d with ab187278 at 1/100 dilution for 30 minutes at RT.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C4d antibody [C4D204] (AB187278)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded kidney transplant tissue labeling C4d with ab187278 at 1/100 dilution for 30 minutes at RT.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C4D204

Isotype

IgG1

Light chain type

kappa

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human C4A.

P0C0L4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Bioreactor concentrate

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

See full target information C4A

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The American journal of pathology 192:564-578 PubMed34954207

2021

Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele.

Applications

Unspecified application

Species

Unspecified reactive species

Jozsef Gal,Yuriko Katsumata,Haining Zhu,Sukanya Srinivasan,Jing Chen,Lance Allen Johnson,Wang-Xia Wang,Lesley Renee Golden,Donna M Wilcock,Gregory A Jicha,Matthew D Cykowski,Peter Tobias Nelson

View all publications

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Product promise

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