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AB11898

Anti-C5 antibody

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(6 Publications)

Rabbit Polyclonal C5 antibody. Suitable for WB and reacts with Mouse samples. Cited in 6 publications.

View Alternative Names

Hc, C5, Complement C5, Hemolytic complement

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C5 also known as complement 5 is a protein with a mass of approximately 190 kDa. This protein plays a mechanical role as part of the complement system within the immune response. C5 is expressed in the bloodstream and is produced mainly by the liver. Upon activation it splits into C5a and C5b where C5a acts as a potent anaphylatoxin while C5b initiates the assembly of the membrane attack complex. Due to its important functions the production and regulation of C5 are tightly controlled within the body.
Biological function summary

The activation of this target contributes significantly to inflammatory processes and host defense. It is part of the larger complement system where it aligns with other complement proteins like C3 and forms a pathway important for immune system functioning. C5 is integral to the terminal complement complex formation which results in the lysis of target cells. The cleavage product C5a has near-instant effects as a chemotactic agent recruiting other immune cells to sites of infection.

Pathways

The protein has a fundamental position in the classical and alternative complement pathways. These pathways converge at the level of C5 where its cleavage is necessary for further downstream effects. C5 interacts extensively with C3 in these pathways highlighting their joint role in amplifying the immune response. The membrane attack complex which C5 helps initiate is a vital endpoint in these pathways promoting the destruction of pathogen cell membranes.

C5 has been linked to conditions like hereditary angioedema and atypical hemolytic uremic syndrome. Dysregulation of C5 or its pathways can lead to chronic inflammation excessive tissue damage or inefficient pathogen clearance. In such conditions related proteins like C3 also show altered activity patterns. Targeting C5 with specific antibodies has emerged as a therapeutic strategy to manage these diseases aiming to mitigate the pathological activation of the complement system.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.. C5a anaphylatoxin. Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
See full target information C5
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:970938 PubMed36304458

2022

The C1q-ApoE complex: A new hallmark pathology of viral hepatitis and nonalcoholic fatty liver disease.

Applications

Unspecified application

Species

Unspecified reactive species

Livia K L Habenicht,Zhihua Wang,Xi Zhang,Yuanfang Li,Carolin Mogler,Julia Slotta Huspenina,Roland M Schmid,Christian Weber,Sarajo K Mohanta,Zhe Ma,Changjun Yin

JCI insight 7: PubMed35167491

2022

Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Chung Tsao,Erika J Crosby,Timothy N Trotter,Junping Wei,Tao Wang,Xiao Yang,Amanda N Summers,Gangjun Lei,Christopher A Rabiola,Lewis A Chodosh,William J Muller,Herbert Kim Lyerly,Zachary C Hartman

Scientific reports 12:1700 PubMed35105928

2022

Promotion of the inflammatory response in mid colon of complement component 3 knockout mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Ju Choi,Ji Eun Kim,Su Jin Lee,Jeong Eun Gong,You Jeong Jin,Ho Lee,Dae Youn Hwang

Nature medicine 25:496-506 PubMed30692699

2019

ApoE attenuates unresolvable inflammation by complex formation with activated C1q.

Applications

Unspecified application

Species

Unspecified reactive species

Changjun Yin,Susanne Ackermann,Zhe Ma,Sarajo K Mohanta,Chuankai Zhang,Yuanfang Li,Sandor Nietzsche,Martin Westermann,Li Peng,Desheng Hu,Sai Vineela Bontha,Prasad Srikakulapu,Michael Beer,Remco T A Megens,Sabine Steffens,Markus Hildner,Luke D Halder,Hans-Henning Eckstein,Jaroslav Pelisek,Jochen Herms,Sigrun Roeber,Thomas Arzberger,Anna Borodovsky,Livia Habenicht,Christoph J Binder,Christian Weber,Peter F Zipfel,Christine Skerka,Andreas J R Habenicht

Nature communications 9:4186 PubMed30305631

2018

Complement receptor CD46 co-stimulates optimal human CD8 T cell effector function via fatty acid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Giuseppina Arbore,Erin E West,Jubayer Rahman,Gaelle Le Friec,Nathalie Niyonzima,Mehdi Pirooznia,Ilker Tunc,Polychronis Pavlidis,Nicholas Powell,Yuesheng Li,Poching Liu,Aude Servais,Lionel Couzi,Veronique Fremeaux-Bacchi,Leo Placais,Alastair Ferraro,Patrick R Walsh,David Kavanagh,Behdad Afzali,Paul Lavender,Helen J Lachmann,Claudia Kemper

The American journal of pathology 175:412-21 PubMed19541934

2009

Complement factor h is critical in the maintenance of retinal perfusion.

Applications

IHC-FoFr

Species

Mouse

Peter Lundh von Leithner,Jaimie Hoh Kam,James Bainbridge,Ian Catchpole,Gerald Gough,Peter Coffey,Glen Jeffery
View all publications
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