JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB235404

Anti-C5orf24 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal C5orf24 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UPF0461 protein C5orf24 aa 1 to C-terminus.

View Alternative Names

UPF0461 protein C5orf24, C5orf24

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5orf24 antibody (AB235404)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5orf24 antibody (AB235404)

Paraffin-embedded human kidney tissue stained for C5orf24 using ab235404 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-C5orf24 antibody (AB235404)
  • WB

Supplier Data

Western blot - Anti-C5orf24 antibody (AB235404)

All lanes:

Western blot - Anti-C5orf24 antibody (ab235404) at 1/1000 dilution

Lane 1:

Mouse gonadal tissue lysate

Lane 2:

K562 (human chronic myelogenous leukemia cell line from bone marrow) whole cell lysate

Lane 3:

THP-1 (human monocytic leukemia cell line) whole cell lysate

Lane 4:

U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell lysate

Lane 5:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Lane 6:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 20 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human UPF0461 protein C5orf24 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q7Z6I8

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C5orf24 also known as Chromosome 5 open reading frame 24 is a protein with a molecular weight of approximately 54 kDa. This protein is expressed in various tissues but shows higher expression levels in the brain and liver suggesting its importance in these organs. The mechanical function of C5orf24 involves interactions with other cellular components though exact binding partners are still under investigation. Current research indicates potential involvement in cellular signaling or maintenance functions.
Biological function summary

The function of Chromosome 5 open reading frame 24 involves regulatory roles within the cell. Although not yet confirmed as part of a larger complex C5orf24 may participate in cellular processes such as proliferation and differentiation based on its expression pattern and interactions. These processes hint at a role in overall cellular health and development aligning with its presence in vital tissues like the brain and liver.

Pathways

Protein C5orf24 is implicated in essential signaling pathways including the PI3K/AKT pathway which influences cell survival and growth. This pathway is critical for transmitting signals from various growth factors and cytokines. Additionally C5orf24 might interact with proteins such as AKT and mTOR which are key players in cellular metabolism and growth regulation. This involvement in major pathways points to its potential as a modulatory protein within complex cellular networks.

Research suggests that Chromosome 5 open reading frame 24 could have links to neurodegenerative diseases like Alzheimer's disease. Altered expression levels of C5orf24 in the brain may contribute to disease progression through its interaction with proteins such as Tau which is associated with neurofibrillary tangles. Furthermore C5orf24 may play a role in liver diseases possibly connected to disrupted cellular stress responses linking it with pathways involving proteins like ATF6 a regulator in the unfolded protein response.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information UPF0461 protein C5orf24
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:106468 PubMed37091236

2023

Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18.

Applications

Unspecified application

Species

Unspecified reactive species

Dawadschargal Dubiel,Jing Wang,Roland Hartig,Supattra Chaithongyot,Wolfgang Dubiel,Michael Naumann
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB237811

Anti-ZNF695 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF695 antibody (AB237811)

  • 0
  • 0
Primary Antibodies

AB235355

Anti-ZMAT5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMAT5 antibody (AB235355)

  • 0
  • 0
Primary Antibodies

AB176689

Anti-ZNF384 antibody

Immunoprecipitation - Anti-ZNF384 antibody (AB176689)

  • 5
  • 1
Primary Antibodies

AB235784

Anti-XRRA1 antibody

Western blot - Anti-XRRA1 antibody (AB235784)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com