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AB150917

Anti-C5orf45 antibody

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(4 Publications)

Rabbit Polyclonal C5orf45 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MRNIP aa 50-200.

View Alternative Names

C5orf45, MRNIP, MRN complex-interacting protein, MRN-interacting protein

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5orf45 antibody (AB150917)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5orf45 antibody (AB150917)

Immunohistochemical analysis of human endometrium tissue labeling C5orf45 in the nucleus of glandular cells with ab150917 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunocytochemistry/ Immunofluorescence - Anti-C5orf45 antibody (AB150917)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-C5orf45 antibody (AB150917)

Immunocytochemical analysis of A431 (Human epidermoid carcinoma cell line) whole cells labeling C5orf45 in the plasma membrane and cytoplasm with ab150917 at 2 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5orf45 antibody (AB150917)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C5orf45 antibody (AB150917)

Immunohistochemical analysis of human Fallopian tube tissue labeling C5orf45 in the nucleus of glandular cells with ab150917 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MRNIP aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q6NTE8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C5orf45 also known as Chromosome 5 open reading frame 45 is a protein encoded by the C5orf45 gene. This protein has an approximate mass of 27 kDa. It is mainly expressed in the brain tissue and other areas at lower levels indicating a potential specialized function. Structurally C5orf45's exact mechanical function is not fully understood which suggests that more research may be required for the determination of its precise role in cellular mechanisms.
Biological function summary

C5orf45 may contribute to cellular development processes in the brain. It has been suggested that C5orf45 interacts with other proteins to form functional complexes that may facilitate cell communication or growth regulation. These interactions make it valuable for proper cellular function especially in neural networks where timing and precision are important. The protein does not function in isolation but likely co-operates as part of larger protein networks.

Pathways

Researchers suggest that C5orf45 might participate in signal transduction pathways related to neurodevelopment. It may interact with proteins in these pathways to influence how neuron signals travel and affect brain development. While specific interactions in these pathways are yet to be conclusively mapped the involvement of C5orf45 alongside other protein regulators like NRP1 (Neuropilin-1) points towards a role in neuronal signaling dynamics.

C5orf45's function potentially links it to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. Some studies have shown changes in the expression levels of C5orf45 in individuals with these conditions. The relationship between C5orf45 and proteins like FMR1 (Fragile X Mental Retardation 1) suggests a complex network may influence the emergence and progression of these disorders. This indicates that C5orf45 may play a contributory role in neurological stability and could be a target for therapeutic research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed : 27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed : 27568553).
See full target information MRNIP
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:2638 PubMed35551189

2022

MRNIP condensates promote DNA double-strand break sensing and end resection.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Long Wang,Wan-Wen Zhao,Shao-Mei Bai,Li-Li Feng,Shu-Ying Bie,Li Gong,Fang Wang,Ming-Biao Wei,Wei-Xing Feng,Xiao-Lin Pang,Cao-Litao Qin,Xin-Ke Yin,Ying-Nai Wang,Weihua Zhou,Daniel R Wahl,Quentin Liu,Ming Chen,Mien-Chie Hung,Xiang-Bo Wan

Science advances 6:eaba5974 PubMed32832601

2020

MRNIP is a replication fork protection factor.

Applications

Unspecified application

Species

Unspecified reactive species

L G Bennett,A M Wilkie,E Antonopoulou,I Ceppi,A Sanchez,E G Vernon,A Gamble,K N Myers,S J Collis,P Cejka,C J Staples

Journal of dermatological science 92:97-105 PubMed30017509

2018

Phenotypic and lipidomic characterization of primary human epidermal keratinocytes exposed to simulated solar UV radiation.

Applications

Unspecified application

Species

Unspecified reactive species

Núria Dalmau,Nathalie Andrieu-Abadie,Romà Tauler,Carmen Bedia

Cell reports 16:2565-2575 PubMed27568553

2016

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher J Staples,Giancarlo Barone,Katie N Myers,Anil Ganesh,Ian Gibbs-Seymour,Abhijit A Patil,Ryan D Beveridge,Caroline Daye,Richard Beniston,Sarah Maslen,Ivan Ahel,J Mark Skehel,Spencer J Collis
View all publications
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Product promise

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