AB195313

Anti-C6orf106 antibody

Name: Anti-C6orf106 antibody (ab195313) | Abcam
Brand: Abcam Limited
SKU: AB195313

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal C6orf106 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ILRUN aa 200 to C-terminus.

View Alternative Names

C6orf106, ILRUN, Protein ILRUN, Inflammation and lipid regulator with UBA-like and NBR1-like domains protein

2 Images

Supplier Data

Immunoprecipitation - Anti-C6orf106 antibody (AB195313)

Immunoprecipitation. ab195313 at 1 μg/ml staining C6orf106 in 293T whole cell lysate immunoprecipitated using ab195313 at 6 μg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Lane 2 : controle IgG.

All lanes:

Immunoprecipitation - Anti-C6orf106 antibody (ab195313)

Predicted band size: 33 kDa

true

Exposure time: 30s

Supplier Data

Western blot - Anti-C6orf106 antibody (AB195313)

All lanes:

Western blot - Anti-C6orf106 antibody (ab195313) at 0.4 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

293T whole cell lysate at 50 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Lane 4:

TCMK-1 whole cell lysate at 50 µg

Lane 5:

NIH3T3 whole cell lysate at 50 µg

Predicted band size: 33 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human ILRUN aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9H6K1

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C6orf106 also known as Chromosome 6 Open Reading Frame 106 is a protein whose precise mechanical function is still undergoing research. It has an approximate molecular mass of 24 kDa. Scientists have observed its expression widely across various tissues with notable presence in the immune system suggesting an important role in immune responses. Although investigations into its complete roles are ongoing C6orf106 is gaining attention due to its potential significance in cellular processes.

Biological function summary

C6orf106 influences gene regulation and immune function. The protein interacts with several partners within the cell although concrete details about a specific complex are yet to be confirmed. Its expression patterns suggest it may play a role in cellular communication and signaling processes. Current research indicates that C6orf106 possibly interacts with pathways that involve transcriptional regulation which highlights its importance in controlling cellular activities that impact broader system functions such as immunity.

Pathways

C6orf106 becomes active in those related to immune system signaling and transcriptional regulation. Notable pathways include the JAK-STAT signaling pathway essential in transmitting information from extracellular signals to the nucleus and potentially the NF-kB pathway known for its role in inflammatory responses. Links to key proteins such as STAT3 in these pathways indicate that C6orf106 could influence important regulatory mechanisms that maintain immune homeostasis and response.

C6orf106 has connections with immune-related conditions and autoimmune diseases. Research suggests potential links to rheumatoid arthritis where its role in immune signaling may contribute to inflammation and joint damage. There is also an interest in its association with chronic inflammatory conditions. Investigations explore its interactions with proteins like TNF-alpha as these connections might provide insights into how C6orf106 may influence disease progression and severity. Understanding these relationships is critical to potentially developing targeted therapies in the future.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed : 29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed : 29802199).

See full target information ILRUN

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell biology international 49:288-302 PubMed39687949

2024

Wilms' tumor 1-associated protein aggravates ischemic stroke by promoting M1 polarization of microglia by enhancing PTGS2 mRNA stability in an m6A-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Haijing Sui,Chang Liu,Zhenyu Sun,Hongjie Xi

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-C6orf106 antibody

Immunoprecipitation - Anti-C6orf106 antibody (AB195313)

Western blot - Anti-C6orf106 antibody (AB195313)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise