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AB122705

Anti-C6orf138 antibody

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(1 Publication)

Rabbit Polyclonal C6orf138 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTCHD4 aa 800 to C-terminus.

View Alternative Names

C6orf138, PTCH53, PTCHD4, Patched domain-containing protein 4, p53-regulated patched protein

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (AB122705)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (AB122705)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate tissue, labeling C6orf138 with ab122705 at 1/500.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (AB122705)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (AB122705)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human stomach tissue, labeling C6orf138 with ab122705 at 1/500.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (AB122705)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (AB122705)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human Fallopian tube tissue, labeling C6orf138 with ab122705 at 1/500.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (AB122705)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (AB122705)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human cerebellum tissue, labeling C6orf138 with ab122705 at 1/500.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PTCHD4 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6ZW05

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C6orf138 also known as vacuolar protein sorting 13 homolog D-like is a protein with a molecular weight of approximately 87 kDa. This protein is expressed in various tissues with notable expression in the brain and testis. C6orf138 participates in intracellular transport processes exhibiting functions within the cytoskeleton and membrane dynamics. Its interactions with other proteins contribute to essential cellular functions positioning it as a notable element in cell biology.
Biological function summary

The protein coded by the C6orf138 gene engages in significant cellular processes particularly those involving endosomal transport and organelle dynamics. Its involvement in complex cellular mechanisms implies a role in vesicle trafficking and protein sorting. Evidence suggests that it may interact as part of a larger protein network that contributes to maintaining cellular homeostasis particularly under physiological stress.

Pathways

This protein participates in the endocytic pathway which facilitates material exchange between the cell surface and the intracellular environment. Its interactions with proteins such as clathrin and dynamin highlight its involvement in vesicle formation and transport. C6orf138's role in cytoskeletal rearrangement underlines its participation in pathways that govern cellular shape and motility relevant to maintaining cellular integrity.

The malfunction of C6orf138 has been associated with neurological conditions such as Alzheimer's disease due to its involvement in protein trafficking and recycling. Additionally the perturbation of its function can connect to mitochondrial-associated degenerative diseases possibly through its relation with proteins like tau and synaptophysin. Understanding its mechanisms could guide therapeutic approaches for treating such conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells.
See full target information PTCHD4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PLoS genetics 16:e1008721 PubMed32339198

2020

Mutations in SPATA13/ASEF2 cause primary angle closure glaucoma.

Applications

Unspecified application

Species

Unspecified reactive species

Naushin H Waseem,Sancy Low,Amna Z Shah,Deepa Avisetti,Pia Ostergaard,Michael Simpson,Katarzyna A Niemiec,Belen Martin-Martin,Hebah Aldehlawi,Saima Usman,Pak Sang Lee,Anthony P Khawaja,Jonathan B Ruddle,Ameet Shah,Ege Sackey,Alexander Day,Yuzhen Jiang,Geoff Swinfield,Ananth Viswanathan,Giovanna Alfano,Christina Chakarova,Heather J Cordell,David F Garway-Heath,Peng T Khaw,Shomi S Bhattacharya,Ahmad Waseem,Paul J Foster
View all publications
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Product promise

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