Rabbit Polyclonal C6orf138 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PTCHD4 aa 800 to C-terminus.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PTCHD4 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZW05
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target data
Function
Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells.
Alternative names
C6orf138, PTCH53, PTCHD4, Patched domain-containing protein 4, p53-regulated patched protein
Recommended products
Rabbit Polyclonal C6orf138 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PTCHD4 aa 800 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PTCHD4 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZW05
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
C6orf138 also known as vacuolar protein sorting 13 homolog D-like is a protein with a molecular weight of approximately 87 kDa. This protein is expressed in various tissues with notable expression in the brain and testis. C6orf138 participates in intracellular transport processes exhibiting functions within the cytoskeleton and membrane dynamics. Its interactions with other proteins contribute to essential cellular functions positioning it as a notable element in cell biology.
- Biological function summary
The protein coded by the C6orf138 gene engages in significant cellular processes particularly those involving endosomal transport and organelle dynamics. Its involvement in complex cellular mechanisms implies a role in vesicle trafficking and protein sorting. Evidence suggests that it may interact as part of a larger protein network that contributes to maintaining cellular homeostasis particularly under physiological stress.
- Pathways
This protein participates in the endocytic pathway which facilitates material exchange between the cell surface and the intracellular environment. Its interactions with proteins such as clathrin and dynamin highlight its involvement in vesicle formation and transport. C6orf138's role in cytoskeletal rearrangement underlines its participation in pathways that govern cellular shape and motility relevant to maintaining cellular integrity.
- Associated diseases and disorders
The malfunction of C6orf138 has been associated with neurological conditions such as Alzheimer's disease due to its involvement in protein trafficking and recycling. Additionally the perturbation of its function can connect to mitochondrial-associated degenerative diseases possibly through its relation with proteins like tau and synaptophysin. Understanding its mechanisms could guide therapeutic approaches for treating such conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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4 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (ab122705)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human cerebellum tissue, labeling C6orf138 with ab122705 at 1/500.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (ab122705)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human stomach tissue, labeling C6orf138 with ab122705 at 1/500.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (ab122705)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human Fallopian tube tissue, labeling C6orf138 with ab122705 at 1/500.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf138 antibody (ab122705)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate tissue, labeling C6orf138 with ab122705 at 1/500.
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