Rabbit Polyclonal C6orf57 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SDHAF4 aa 1 to C-terminus.
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
IHC-P | ICC | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/20.00000 - 1/50.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info - | Notes Fixation/Permeabilization: PFA/Triton X-100 |
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity).
C6orf57, SDHAF4, SDH assembly factor 4
Rabbit Polyclonal C6orf57 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SDHAF4 aa 1 to C-terminus.
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
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C6orf57 also known as Chromosome 6 Open Reading Frame 57 is a protein that does not yet have a well-defined function. It has a molecular mass of approximately 17 kDa. Researchers have observed its expression in a variety of tissues although specific expression patterns remain to be fully explored. Some initial studies suggest its possible involvement in cellular processes but more research is necessary to pinpoint precise functions.
Many traditional biological functions of C6orf57 are still under investigation with current data indicating that it might be involved in protein interactions rather than being part of specific complexes. Some studies suggest that C6orf57 could potentially influence regulatory mechanisms at the cellular level. Its actual protein interaction partners and biological roles remain relatively unexplored posing interesting questions for further experimental analysis.
Existing knowledge gives limited insight into where C6orf57 fits into specific biological networks. However some indications point to its participation in pathways involving basic cellular functions such as signaling or metabolic processes. Its interactions with other proteins like those in key pathways need more detailed investigation to determine the full picture. The lack of direct involvement in well-studied pathways makes C6orf57 a target of interest for new pathway elucidation.
Researchers have not conclusively established direct links between C6orf57 and specific diseases. However there is initial interest in possible associations with certain cellular dysfunctions due to its widespread expression pattern. No defined connection exists with well-known disease-related proteins but continued research may uncover potential correlations with certain pathologies enlightening its role within those contexts.
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Immunocytochemistry/immunofluorescence analysis of human cell line A-431 labelling C6orf57 with ab122196 at 2 μg/mL.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human small intestine tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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