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AB122196

Anti-C6orf57 antibody

1

(2 Reviews)

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(1 Publication)

Rabbit Polyclonal C6orf57 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SDHAF4 aa 1 to C-terminus.

View Alternative Names

C6orf57, SDHAF4, SDH assembly factor 4

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human small intestine tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunocytochemistry - Anti-C6orf57 antibody (AB122196)
  • ICC

Unknown

Immunocytochemistry - Anti-C6orf57 antibody (AB122196)

Immunocytochemistry/immunofluorescence analysis of human cell line A-431 labelling C6orf57 with ab122196 at 2 μg/mL.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SDHAF4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q5VUM1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C6orf57 also known as Chromosome 6 Open Reading Frame 57 is a protein that does not yet have a well-defined function. It has a molecular mass of approximately 17 kDa. Researchers have observed its expression in a variety of tissues although specific expression patterns remain to be fully explored. Some initial studies suggest its possible involvement in cellular processes but more research is necessary to pinpoint precise functions.
Biological function summary

Many traditional biological functions of C6orf57 are still under investigation with current data indicating that it might be involved in protein interactions rather than being part of specific complexes. Some studies suggest that C6orf57 could potentially influence regulatory mechanisms at the cellular level. Its actual protein interaction partners and biological roles remain relatively unexplored posing interesting questions for further experimental analysis.

Pathways

Existing knowledge gives limited insight into where C6orf57 fits into specific biological networks. However some indications point to its participation in pathways involving basic cellular functions such as signaling or metabolic processes. Its interactions with other proteins like those in key pathways need more detailed investigation to determine the full picture. The lack of direct involvement in well-studied pathways makes C6orf57 a target of interest for new pathway elucidation.

Researchers have not conclusively established direct links between C6orf57 and specific diseases. However there is initial interest in possible associations with certain cellular dysfunctions due to its widespread expression pattern. No defined connection exists with well-known disease-related proteins but continued research may uncover potential correlations with certain pathologies enlightening its role within those contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed : 24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity).
See full target information SDHAF4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:902 PubMed40804742

2025

Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Geng Peng,Lin Zhong,Lina Luo,Yongle Ju,Yan Lu,Lui Ng,Dominic Chi-Chung Foo,Fu Cheng,Luji Huang,Manzhao Ouyang
View all publications
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Product promise

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