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Rabbit Polyclonal C6orf57 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SDHAF4 aa 1 to C-terminus.


Images

Immunocytochemistry - Anti-C6orf57 antibody (AB122196), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (AB122196), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human SDHAF4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q5VUM1

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PICC
Human
Tested
Tested

Tested
Tested

Species
Human
Dilution info
1/20.00000 - 1/50.00000
Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Tested
Tested

Species
Human
Dilution info
-
Notes

Fixation/Permeabilization: PFA/Triton X-100

Target data

Function

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal C6orf57 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SDHAF4 aa 1 to C-terminus.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Recombinant Fragment Protein within Human SDHAF4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q5VUM1
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

C6orf57 also known as Chromosome 6 Open Reading Frame 57 is a protein that does not yet have a well-defined function. It has a molecular mass of approximately 17 kDa. Researchers have observed its expression in a variety of tissues although specific expression patterns remain to be fully explored. Some initial studies suggest its possible involvement in cellular processes but more research is necessary to pinpoint precise functions.

Biological function summary

Many traditional biological functions of C6orf57 are still under investigation with current data indicating that it might be involved in protein interactions rather than being part of specific complexes. Some studies suggest that C6orf57 could potentially influence regulatory mechanisms at the cellular level. Its actual protein interaction partners and biological roles remain relatively unexplored posing interesting questions for further experimental analysis.

Pathways

Existing knowledge gives limited insight into where C6orf57 fits into specific biological networks. However some indications point to its participation in pathways involving basic cellular functions such as signaling or metabolic processes. Its interactions with other proteins like those in key pathways need more detailed investigation to determine the full picture. The lack of direct involvement in well-studied pathways makes C6orf57 a target of interest for new pathway elucidation.

Associated diseases and disorders

Researchers have not conclusively established direct links between C6orf57 and specific diseases. However there is initial interest in possible associations with certain cellular dysfunctions due to its widespread expression pattern. No defined connection exists with well-known disease-related proteins but continued research may uncover potential correlations with certain pathologies enlightening its role within those contexts.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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5 product images

  • Immunocytochemistry - Anti-C6orf57 antibody (ab122196), expandable thumbnail

    Immunocytochemistry - Anti-C6orf57 antibody (ab122196)

    Immunocytochemistry/immunofluorescence analysis of human cell line A-431 labelling C6orf57 with ab122196 at 2 μg/mL.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (ab122196), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (ab122196)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (ab122196), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (ab122196)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (ab122196), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (ab122196)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human small intestine tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (ab122196), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf57 antibody (ab122196)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling C6orf57 with ab122196 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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