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AB121711

Anti-C7orf51 antibody

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(1 Publication)

Rabbit Polyclonal C7orf51 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NYAP1 aa 500-650.

View Alternative Names

C7orf51, NYAP1, Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C7orf51 antibody (AB121711)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C7orf51 antibody (AB121711)

ab121711, at 1/50 dilution, staining C7orf51 in paraffin-embedded Human duodenum tissue, by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-C7orf51 antibody (AB121711)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-C7orf51 antibody (AB121711)

Immunofluorescent staining of Human cell line A-431 shows positivity in cytoplasm. Recommended concentration of ab121711 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Western blot - Anti-C7orf51 antibody (AB121711)
  • WB

Unknown

Western blot - Anti-C7orf51 antibody (AB121711)

All lanes:

Western blot - Anti-C7orf51 antibody (ab121711) at 1/250 dilution

Lane 1:

RT-4 cells lysate

Lane 2:

U-251 MG cells lysate

Lane 3:

Human plasma lysate

Lane 4:

Human Liver lysate

Lane 5:

Human Tonsil lysate

Predicted band size: 88 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human NYAP1 aa 500-650. The exact immunogen used to generate this antibody is proprietary information.

Q6ZVC0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/250 - 1/500", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C7orf51 also known as UPF0670 protein C7orf51 is a protein with a molecular weight of approximately 26 kDa. It is expressed in various tissues with higher expression observed in the liver and kidney. Mechanically C7orf51 is involved in intracellular signaling and cellular homeostasis. Its role may include acting as a scaffold or facilitator in larger protein complexes although its precise molecular functions are still under investigation.
Biological function summary

The protein contributes to cellular processes such as cell growth and maintenance. C7orf51 is often part of multi-protein complexes that modulate cellular responses to environmental changes. These complexes can influence metabolic processes and affect the stability of other intracellular proteins. Its interaction partners suggest a role in managing the balance between cell proliferation and apoptosis especially under stress conditions.

Pathways

C7orf51 interacts with several intracellular signaling cascades including the AKT signaling pathway and the mTOR pathway. These pathways are critical for regulating cell growth survival and metabolism. Within these pathways C7orf51 is thought to interact with proteins like AKT1 and MTOR modulating their activity to ensure appropriate cellular responses to external stimuli such as nutrient availability and hormonal signals.

Research implicates C7orf51 in metabolic disorders and cancer. Metabolic syndrome might involve dysregulation of pathways where C7orf51 plays a role affecting energy homeostasis and lipid metabolism. In cancer alterations in the pathways associated with C7orf51 like the mTOR pathway contribute to unchecked cell proliferation. Associations with proteins like AKT1 and MTOR in these diseases highlight the importance of C7orf51's regulatory function in these pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.
See full target information NYAP1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 13: PubMed40427044

2025

The Expression and Molecular Roles of MAMDC2 in MSS Colorectal Cancer with a High Tumor Stromal Ratio.

Applications

Unspecified application

Species

Unspecified reactive species

Yiling Liu,Shengnan Qian,Jia Wei,Jianting He,Minghui Li,Xiaobing Gao,Hong Cai,Yiqing Wang,Yue Han,Tianyuan Tan,Minhui Yang
View all publications
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Product promise

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