Rabbit Polyclonal C8orf55 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human THEM6 aa 100 to C-terminus.
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- EMBO molecular medicine 14:e147642022THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesArnaud Blomme,Coralie Peter,Ernest Mui,Giovanny Rodriguez Blanco,Ning An,Louise M Mason,Lauren E Jamieson,Grace H McGregor,Sergio Lilla,Chara Ntala,Rachana Patel,Marc Thiry,Sonia H Y Kung,Marine Leclercq,Catriona A Ford,Linda K Rushworth,David J McGarry,Susan Mason,Peter Repiscak,Colin Nixon,Mark J Salji,Elke Markert,Gillian M MacKay,Jurre J Kamphorst,Duncan Graham,Karen Faulds,Ladan Fazli,Martin E Gleave,Edward Avezov,Joanne Edwards,Huabing Yin,David Sumpton,Karen Blyth,Pierre Close,Daniel J Murphy,Sara Zanivan,Hing Y LeungPubMed 35014179
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human THEM6 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8WUY1
Reactivity data
Select an application| IHC-P | ICC | WB | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
Target data
Alternative names
C8orf55, PSEC0098, THEM6, Protein THEM6, Mesenchymal stem cell protein DSCD75, Thioesterase superfamily member 6
Recommended products
Rabbit Polyclonal C8orf55 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human THEM6 aa 100 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human THEM6 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8WUY1
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
C8orf55 is also known as Chromosome 8 Open Reading Frame 55. It is a protein with a molecular mass of approximately 23 kDa. Researchers have identified this protein in several tissues but it shows higher expression in the heart and skeletal muscles. The exact molecular mechanisms of C8orf55 remain under investigation but it appears to play a role in cellular processes such as metabolism or regulation of energy.
- Biological function summary
Scientists see C8orf55 as integral in energy production and utilization within muscle tissues. While no established complex houses C8orf55 its functional significance suggests interactions with key metabolic proteins possibly occur. The protein's role hints at involvement in critical cellular efficiency processes and may impact muscle function and maintenance by influencing metabolic pathways.
- Pathways
C8orf55 interacts significantly within cellular metabolic pathways particularly those involving mitochondrial function. It associates with the oxidative phosphorylation pathway an important energy-generation pathway. C8orf55 may relate to proteins such as ATP synthase through its involvement in producing cellular energy. Researchers speculate links with the electron transport chain connecting C8orf55 to essential bioenergetic processes.
- Associated diseases and disorders
C8orf55's role in metabolism indicates potential links to metabolic myopathies and heart-related conditions. The protein's involvement in energy pathways suggests that disruptions could associate with conditions like cardiomyopathy which affect heart muscles. Connections exist with proteins like creatine kinase hinting at broader implications for muscular energy diseases where C8orf55 could significantly impact the understanding or treatment of such disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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6 product images
Immunocytochemistry - Anti-C8orf55 antibody (ab121743)
Immunofluorescent staining of Human cell line U-251MG shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab121743 is 0.04 μg/ml. Cells treated with PFA/Triton X-100.
Western blot - Anti-C8orf55 antibody (ab121743)
All lanes: Western blot - Anti-C8orf55 antibody (ab121743) at 0.04 µg/mL
Lane 1: RT-4 lysate
Lane 2: U-251 MG lysate
Lane 3: Human plasma
Lane 4: Human liver lysate
Lane 5: Human tonsil lysate
Developed using the ECL technique.
Predicted band size: 24 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C8orf55 antibody (ab121743)
ab121743, at a 1/1000 dilution staining C8orf55 in paraffin-embedded Human small intestine tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C8orf55 antibody (ab121743)
ab121743, at a 1/1000 dilution staining C8orf55 in paraffin-embedded Human kidney tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C8orf55 antibody (ab121743)
ab121743, at a 1/1000 dilution staining C8orf55 in paraffin-embedded Human fallopian tube tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C8orf55 antibody (ab121743)
ab121743, at a 1/1000 dilution staining C8orf55 in paraffin-embedded Human cerebellum tissue by Immunohistochemistry.
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