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AB237525

Anti-C9ORF46/PLGRKT antibody

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(2 Publications)

Rabbit Polyclonal C9ORF46/PLGRKT antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PLGRKT.

View Alternative Names

C9orf46, AD025, MDS030, PLGRKT, Plasminogen receptor (KT), Plg-R(KT)

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C9ORF46/PLGRKT antibody (AB237525)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C9ORF46/PLGRKT antibody (AB237525)

Paraffin-embedded human skin tissue stained for C9ORF46/PLGRKT using ab237525 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-C9ORF46/PLGRKT antibody (AB237525)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-C9ORF46/PLGRKT antibody (AB237525)

U-251 MG (Human brain glioma cell line) cells stained for C9ORF46/PLGRKT (green) using ab237525 at 1/100 dilution in ICC/IF. Secondary antibody is an Alexa-Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-C9ORF46/PLGRKT antibody (AB237525)
  • WB

Supplier Data

Western blot - Anti-C9ORF46/PLGRKT antibody (AB237525)

All lanes:

Western blot - Anti-C9ORF46/PLGRKT antibody (ab237525) at 1/500 dilution

Lane 1:

A431 (Human epidermoid carcinoma cell line) whole cell lysate

Lane 2:

Mouse lung tissue lysate

Lane 3:

NIH/3T3 (Mouse embryo fibroblast cell line) whole cell lysate

Lane 4:

U-251 MG (Human brain glioma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 17 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C9ORF46/PLGRKT antibody (AB237525)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C9ORF46/PLGRKT antibody (AB237525)

Paraffin-embedded human colon cancer tissue stained for C9ORF46/PLGRKT using ab237525 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PLGRKT.

Q9HBL7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C9ORF46 also known as PLGRKT is a protein encoded by the C9ORF46 gene. It has a molecular mass of approximately 28 kDa. Scientists have detected its expression in various tissues with particular enrichment in neurons. This protein consists of a unique domain structure including a combination of leucine-rich domains. As an intracellular component PLGRKT may interact with other proteins or membranes within the cell.
Biological function summary

C9ORF46/PLGRKT plays a role in cellular processes that involve the regulation of fibrinolysis. It does not act in isolation and is known to be part of complexes that modulate other proteins' activity. The protein serves as an important mediator in tissue remodeling and wound healing. By interacting with enzymes such as plasminogen it influences the actions on the extracellular matrix components affecting cell migration and tissue repair mechanisms.

Pathways

C9ORF46 influences the plasminogen activation system. This protein's role in the fibrinolytic pathway is key for promoting the breakdown of fibrin a protein involved in blood clotting. Additionally C9ORF46 is related to the urokinase-type plasminogen activator (uPA) through this pathway. Together they coordinate in controlling the conversion of plasminogen to its active form plasmin which degrades fibrin and other matrix proteins.

C9ORF46/PLGRKT is linked to the regulation of processes relevant to thrombotic conditions. Abnormal function or expression of this protein can contribute to disorders of fibrinolysis such as thrombosis. Moreover its interaction with other proteins like the aforementioned plasminogen can lead to impaired wound healing. Understanding the precise relationship between C9ORF46 and these conditions could reveal potential therapeutic targets for treatment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9.
See full target information PLGRKT
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

BMC cancer 24:508 PubMed39103807

2024

Identification and validation of genes associated with prognosis of cisplatin-resistant ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Dajiang Liu,Ruiyun Li,Yidan Wang,Dan Li,Leilei Li

Oncology reports 51: PubMed38624012

2024

Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Keshab Raj Parajuli,Younghun Jung,Russell S Taichman
View all publications
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Product promise

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