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AB111866

Anti-C9orf86 antibody

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(1 Publication)

Rabbit Polyclonal C9orf86 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RABL6 aa 1-250.

View Alternative Names

C9orf86, PARF, RABL6, Rab-like protein 6, GTP-binding protein Parf, Partner of ARF, Rab-like protein 1, RBEL1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-C9orf86 antibody (AB111866)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-C9orf86 antibody (AB111866)

ab111866 at 1/200 dilution staining C9orf86 in paraformaldehyde-fixed A431 cells by Immunofluorescence. The lower panel is costained with Hoechst 33342.

Western blot - Anti-C9orf86 antibody (AB111866)
  • WB

Unknown

Western blot - Anti-C9orf86 antibody (AB111866)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-C9orf86 antibody (ab111866) at 1/5000 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 80 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human RABL6 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q3YEC7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab111866 is purified by antigen-affinity chromatography.
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C9orf86 also known as chromosome 9 open reading frame 86 is a protein-coding gene. Although its exact molecular mechanism remains under investigation preliminary data indicate its involvement in transcriptional regulation. C9orf86 possesses a molecular weight of approximately 19 kDa. Expression of C9orf86 occurs in various tissues with heightened levels identified in the cerebral cortex suggesting potential neural functions.
Biological function summary

This protein is implicated in a spectrum of cellular processes including gene expression and possibly signal transduction. Research indicates C9orf86 might participate in regulatory complexes that influence chromatin remodeling. This involvement could affect transcriptional responses to cellular stimuli and contribute to maintaining cellular homeostasis.

Pathways

C9orf86 potentially links to the Wnt signaling pathway impacting cell proliferation and differentiation. It may interact with proteins such as beta-catenin within this pathway to modulate gene transcription. Additionally evidence indicates a partial role in the Notch signaling pathway particularly involving the development and differentiation of neural tissues.

Growing evidence suggests that C9orf86 might associate with neurological disorders like schizophrenia. Variations in C9orf86 expression could influence the pathology of this condition possibly through its interaction with proteins like DISC1. Furthermore altered expression of C9orf86 may also have implications in certain cancers by affecting pathways linked to proliferation and apoptosis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Small GTPase involved in the regulation of cell growth and survival (PubMed : 19433581). Promotes cellular proliferation (PubMed : 16582619, PubMed : 19433581). May reduce growth inhibitory activity of CDKN2A (PubMed : 16582619).
See full target information RABL6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 13:1275-80 PubMed26676380

2015

RBEL1 is required for osteosarcoma cell proliferation via inhibiting retinoblastoma 1.

Applications

Unspecified application

Species

Unspecified reactive species

Honghui Tang,Feng Ji,Jin Sun,Yue Xie,Yongyi Xu,Haitao Yue
View all publications
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Product promise

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