AB3982

Anti-CA19-9 antibody [121SLE]

Name: Anti-CA19-9 antibody [121SLE] Mouse monoclonal (ab3982) | Abcam
Brand: Abcam Limited
SKU: AB3982
Price: 410 USD
Availability: InStock
Rating: 2 (1 reviews)

(1 Review)

(23 Publications )

Mouse Monoclonal CA19-9 antibody. Suitable for Flow Cyt, ELISA, IHC-P and reacts with Human samples. Cited in 23 publications.

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CA19-9 antibody [121SLE] (AB3982)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CA19-9 antibody [121SLE] (AB3982)

ab3982 staining CA19-9 in human colorectal adenocarcinoma by IHC-P (Formalin/Paraformaldehye fixed paraffin embedded tissue sections).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

121SLE

Isotype

IgM

Carrier free

Reacts with

Human

Applications

Flow Cyt, IHC-P, ELISA

applications

Specificity

The antibody recognizes Sialyl Lewis a containing glycolipids.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "" } } }

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Product details

This product was changed from ascites to tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

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Properties and storage information

Form

Liquid

Purification technique

Proprietary technique

Purification notes

Purified from TCS. Purified by precipitation and chromatography. Purity >95% by SDS-PAGE.

Storage buffer

pH: 8 Preservative: 0.097% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Do Not Freeze

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CA19-9 also known as carbohydrate antigen 19-9 or sialyl-Lewis A is a glycoprotein with a molecular mass of around 210 kDa. This antigen is mainly expressed on the surface of epithelial cells in the pancreas liver gallbladder and stomach. It serves as a well-recognized tumor marker for cancers associated with these organs. CA19-9 can be detected using techniques like immunohistochemistry (IHC) aiding in diagnostic and research applications.

Biological function summary

CA19-9 plays a role in cell-cell communication and adhesion contributing to the behavior of cancer cells regarding metastasis and invasion. It is part of a broader complex involving glycoproteins which is important in cell surface recognition and signaling events. In normal cellular roles functions are less prominent but the alterations in cancerous cells highlight its biological significance in oncogenesis.

Pathways

CA19-9 interacts with several signal transduction pathways that influence cellular processes like proliferation and migration. Notably it is involved in the EGF receptor pathway affecting cellular growth and survival mechanisms. It relates to glycosylation pathways which together with other proteins such as MUC1 modify cellular membranes in malignant tissues influencing tumor progression and evasion from immune detection.

CA19-9 frequently connects with pancreatic cancer and cholangiocarcinoma serving as a biomarker for diagnosis and monitoring disease progression. Its levels often increase in response to malignancies in these tissues. Studies suggest its interaction with proteins like CEACAM6 might enhance tumor invasiveness and metastasis. Identifying elevated CA19-9 can guide clinical decisions and therapeutic strategies in affected individuals.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information CA19-9

Alternative Names

CA19.9, Ovarian tumor antigen, Pancreatic tumor antigen, Sialyl Lewis a

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Publications (23)

Recent publications for all applications. Explore the full list and refine your search

Annals of surgery 280:e17-e25 PubMed38050737

2023

Pancreatic Cancer: An Exocrine Tumor With Endocrine Characteristics.

Applications

Unspecified application

Species

Unspecified reactive species

Xinzhe Zhu,Zhiwen Xiao,He Liu,Pin Zhang,Shengming Deng,Lei Ding,Jingjing Feng,Jianfeng Luo,Quanxing Ni,Guopei Luo,Xianjun Yu

Glycobiology 33:637-650 PubMed37486674

2023

Identification of potential classes of glycoligands mediating dynamic endothelial adhesion of human tumor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah Starzonek,Hanna Maar,Stefan Mereiter,Vera Freytag,Marie-Therese Haider,Kristoffer Riecken,Yen-Lin Huang,Francis Jacob,Daniel Wicklein,Udo Schumacher,Tobias Lange

Discover. Oncology 14:20 PubMed36797531

2023

Glutamine is a substrate for glycosylation and CA19-9 biosynthesis through hexosamine biosynthetic pathway in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Liu,Shengming Deng,Zhiwen Xiao,Renquan Lu,He Cheng,Jingjing Feng,Xuxia Shen,Quanxing Ni,Weiding Wu,Xianjun Yu,Guopei Luo

Cancers 14: PubMed36551619

2022

Sialyltransferase Inhibitor Ac3FNeu5Ac Reverts the Malignant Phenotype of Pancreatic Cancer Cells, and Reduces Tumor Volume and Favors T-Cell Infiltrates in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Miró,Júlia López,Pedro E Guerrero,Neus Martínez-Bosch,Noemí Manero-Rupérez,Mireia Moreno,M Rosa Ortiz,Esther Llop,Pilar Navarro,Rosa Peracaula

World journal of surgical oncology 20:266 PubMed36008864

2022

Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Enqi Zheng,Zhun Cai,Wangyong Li,Chuandou Ni,Qian Fang

Bioengineered 13:5525-5536 PubMed35166644

2022

The potential role of methyltransferase-like 5 in deficient mismatch repair of uterine corpus endometrial carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojuan Liu,Hui Ma,Lisha Ma,Kun Li,Yanhua Kang

Methods in molecular biology (Clifton, N.J.) 2460:33-44 PubMed34972929

2022

Multiplex Glycan Bead Array (MGBA ) for High Throughput and High Content Analyses of Glycan-Binding Proteins Including Natural Anti-Glycan Antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Sharad Purohit,Jin-Xiong She

Clinics (Sao Paulo, Brazil) 76:e3318 PubMed34817046

2021

RNA-binding protein with serine-rich domain 1 regulates microsatellite instability of uterine corpus endometrial adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojuan Liu,Hui Ma,Lisha Ma,Kun Li,Yanhua Kang

BioFactors (Oxford, England) 47:865-878 PubMed34339079

2021

CDCA7-regulated inflammatory mechanism through TLR4/NF-κB signaling pathway in stomach adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Guo,Kaimei Zhou,Xiang Zhuang,Junjie Li,Xianglin Shen

Technology in cancer research & treatment 20:1533033821995282 PubMed33602046

2021

The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Lv,Qinghua Xia,Anshu Li,Zhiyong Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CA19-9 antibody [121SLE]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CA19-9 antibody [121SLE] (AB3982)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Specificity

Alternative Products

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Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Alternative Names

Publications (23)

Product promise