Mouse Monoclonal CA19-9 antibody. Suitable for ICC, IHC-P, IHC-Fr and reacts with Human samples. Cited in 3 publications.
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA
| ICC | IHC-P | IHC-Fr | |
|---|---|---|---|
| Human | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
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CA19.9, Ovarian tumor antigen, Pancreatic tumor antigen, Sialyl Lewis a
Mouse Monoclonal CA19-9 antibody. Suitable for ICC, IHC-P, IHC-Fr and reacts with Human samples. Cited in 3 publications.
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA
This product was changed from ascites to tissue culture supernatant on 15th June 2017. The following lots are from ascites and still in stock as of 15th June 2017 (GR199967-1, GR156050-9, GR156050-10). Lot numbers higher than GR156050-10 will be from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly.
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CA19-9 also known as carbohydrate antigen 19-9 or sialyl-Lewis A is a glycoprotein with a molecular mass of around 210 kDa. This antigen is mainly expressed on the surface of epithelial cells in the pancreas liver gallbladder and stomach. It serves as a well-recognized tumor marker for cancers associated with these organs. CA19-9 can be detected using techniques like immunohistochemistry (IHC) aiding in diagnostic and research applications.
CA19-9 plays a role in cell-cell communication and adhesion contributing to the behavior of cancer cells regarding metastasis and invasion. It is part of a broader complex involving glycoproteins which is important in cell surface recognition and signaling events. In normal cellular roles functions are less prominent but the alterations in cancerous cells highlight its biological significance in oncogenesis.
CA19-9 interacts with several signal transduction pathways that influence cellular processes like proliferation and migration. Notably it is involved in the EGF receptor pathway affecting cellular growth and survival mechanisms. It relates to glycosylation pathways which together with other proteins such as MUC1 modify cellular membranes in malignant tissues influencing tumor progression and evasion from immune detection.
CA19-9 frequently connects with pancreatic cancer and cholangiocarcinoma serving as a biomarker for diagnosis and monitoring disease progression. Its levels often increase in response to malignancies in these tissues. Studies suggest its interaction with proteins like CEACAM6 might enhance tumor invasiveness and metastasis. Identifying elevated CA19-9 can guide clinical decisions and therapeutic strategies in affected individuals.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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