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AB248215

Anti-CABP antibody [EPR7916] - BSA and Azide free

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(1 Publication)

Rabbit Recombinant Monoclonal CABP antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Calcium-binding protein 1, CaBP1, Calbrain, Caldendrin, CABP1

1 Images
Western blot - Anti-CABP antibody [EPR7916] - BSA and Azide free (AB248215)
  • WB

Unknown

Western blot - Anti-CABP antibody [EPR7916] - BSA and Azide free (AB248215)

This data was developed using ab128910, the same antibody clone in a different buffer formulation.

All lanes:

Western blot - Anti-CABP antibody [EPR7916] (<a href='/en-us/products/primary-antibodies/cabp-antibody-epr7916-ab128910'>ab128910</a>) at 1/1000 dilution

Lane 1:

Y79 cell lysate at 10 µg

Lane 2:

U-87 MG cell lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 40 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7916

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

ab248215 is the carrier-free version of ab128910.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CABP or Calcium-Binding Protein is a protein that modulates calcium signaling pathways. Alternate names include calbindin and calretinin though these may refer to specific types within the broader CABP family. CABP proteins vary in mass generally ranging from 10 to 50 kDa depending on the specific family member. These proteins are mainly expressed in the nervous system where they play an important role in regulating intracellular calcium levels. They also appear in other tissues like the heart and kidneys where they contribute to various cellular functions.
Biological function summary

The regulation of calcium ions by CABP influences several processes including neurotransmitter release muscle contraction and cell division. CABP proteins can be parts of larger complexes where they interact with other calcium-binding proteins to modulate calcium-dependent signaling mechanisms. Their function in the regulation of calcium homeostasis suggests a direct involvement in maintaining normal cellular functions especially in neurons.

Pathways

CABP proteins play integral roles in calcium signaling and related pathways. They are critical in modulating the response of cells to calcium transients by interacting with proteins such as calmodulin and calcineurin. CABP's role in these calcium-mediated pathways ensures proper synaptic activity and muscle response and is important for the plasticity of neuronal connections critical for learning and memory.

The dysfunction of CABP has links to neurodegenerative disorders and cardiac diseases. Alterations in CABP expression can contribute to conditions like Alzheimer's disease where calcium signaling becomes dysregulated. In addition aberrant CABP function may also play a role in cardiac hypertrophy due to imbalanced calcium handling often involving calmodulin and other calcium-dependent molecules. Understanding CABP's involvement in these conditions could provide insights into potential therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs) (PubMed : 14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed : 15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed : 11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed : 15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed : 15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).
See full target information CABP1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 7:1025 PubMed39164573

2024

CD58 defines regulatory macrophages within the tumor microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Wu,Xiaoni Zhan,Meixi Jiang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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