AB128251

Anti-CACNA1H antibody

Name: Anti-CACNA1H antibody (ab128251) | Abcam
Brand: Abcam Limited
SKU: AB128251
Rating: 1 (1 reviews)

(1 Review)

(3 Publications)

Rabbit Polyclonal CACNA1H antibody. Suitable for ELISA, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CACNA1H.

View Alternative Names

Voltage-dependent T-type calcium channel subunit alpha-1H, Low-voltage-activated calcium channel alpha1 3.2 subunit, Voltage-gated calcium channel subunit alpha Cav3.2, CACNA1H

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ELISA, ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human CACNA1H. The exact immunogen used to generate this antibody is proprietary information.

O95180

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CACNA1H also known as Cav3.2 or T-type calcium channel alpha-1H subunit functions as a voltage-dependent calcium channel. The protein plays a role in the influx of calcium ions into cells. It has a molecular mass of approximately 260.7 kDa. CACNA1H expresses most abundantly in the central nervous system although you can also find it in the heart and various other tissues. This channel is part of the larger Cav3 family of T-type calcium channels which includes other subunits like Cav3.1 and Cav3.3.

Biological function summary

This calcium channel regulates numerous cellular processes through its role in calcium signaling. It does not form part of a complex but still interacts closely with various signaling molecules to influence activities such as neurotransmitter release and muscle contraction. By modulating membrane potentials and synaptic transmission CACNA1H plays a significant direct role in neuronal excitability and rhythmic activities.

Pathways

CACNA1H interacts within the calcium signaling and neurotransmission pathways. In these pathways it regulates calcium ion homeostasis and neuronal excitability working alongside other channels like L-type and N-type calcium channels. CACNA1H affects the excitation-contraction coupling critical for smooth muscle function interlinking with proteins such as calmodulin that respond to changes in calcium ion concentration.

CACNA1H has been linked to epilepsy and neuropathic pain. In epilepsy mutations in CACNA1H can disrupt normal calcium flow affecting neuronal firing patterns and contributing to seizures. Its interaction with other ion channels like SCN1A further influences epileptic manifestations. Mutations may also contribute to neuropathic pain by altering pain threshold and response through its role in pain pathway modifications.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed : 27149520, PubMed : 9670923, PubMed : 9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed : 15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed : 25907736, PubMed : 27729216).

See full target information CACNA1H

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Translational psychiatry 12:234 PubMed35668055

2022

Rare CACNA1H and RELN variants interact through mTORC1 pathway in oligogenic autism spectrum disorder.

Applications

Unspecified application

Species

Unspecified reactive species

André Luíz Teles E Silva,Talita Glaser,Karina Griesi-Oliveira,Juliana Corrêa-Velloso,Jaqueline Yu Ting Wang,Gabriele da Silva Campos,Henning Ulrich,Andrea Balan,Mehdi Zarrei,Edward J Higginbotham,Stephen W Scherer,Maria Rita Passos-Bueno,Andrea Laurato Sertié

Frontiers in cell and developmental biology 9:637233 PubMed34169070

2021

Propofol Mediated Protection of the Brain From Ischemia/Reperfusion Injury Through the Regulation of Microglial Connexin 43.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Zhang,Yanyan Wang,Qin Xia,Zhiyi Tu,Jiajun Sun,Qi Jing,Pei Chen,Xuan Zhao

Molecular medicine reports 17:898-910 PubMed29115500

2017

Roles and mechanisms of TRPC3 and the PLCγ/PKC/CPI-17 signaling pathway in regulating parturition.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Chen,Dongming Zheng,Hong Cui,Sishi Liu,Lijuan Zhang,Caixia Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CACNA1H antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise