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AB230019

Anti-CACNB1/CAB1 antibody

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Rabbit Polyclonal CACNB1/CAB1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CACNB1 aa 400 to C-terminus.

View Alternative Names

CACNLB1, CACNB1, Voltage-dependent L-type calcium channel subunit beta-1, CAB1, Calcium channel voltage-dependent subunit beta 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CACNB1/CAB1 antibody (AB230019)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CACNB1/CAB1 antibody (AB230019)

Paraffin-embedded human brain tissue stained for CACNB1/CAB1 using ab230019 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-CACNB1/CAB1 antibody (AB230019)
  • WB

Supplier Data

Western blot - Anti-CACNB1/CAB1 antibody (AB230019)

All lanes:

Western blot - Anti-CACNB1/CAB1 antibody (ab230019) at 1/1000 dilution

All lanes:

Mouse liver lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 66 kDa

Observed band size: 66 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human CACNB1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q02641

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CACNB1 also known as CAB1 is a protein that forms a part of the voltage-dependent L-type calcium channel complex. It is one of the auxiliary beta subunits and plays an important role in regulating the activity of the channel by stabilizing the alpha 1 subunit's structure. CACNB1 has a molecular weight of approximately 65 kDa. Its expression takes place in various tissues including the heart skeletal muscle and brain which indicates its importance in excitable tissues.
Biological function summary

Several processes depend on CACNB1's function. This protein contributes significantly to modulating calcium ion influx into cells a fundamental function for cellular activities such as muscle contraction neurotransmitter release and gene expression. CACNB1 exists as part of the calcium channel complex and interacts directly with the alpha 1 subunit which influences channel properties and cell surface expression.

Pathways

CACNB1 is integral to the calcium signaling pathway and cardiac muscle contraction pathway. It directly interacts with the alpha 1 subunit of the L-type calcium channels facilitating calcium ion entry that is necessary for proper signal transduction. In these pathways other proteins such as CACNA1C also play a significant role by forming part of the channel complex that mediates these essential physiological effects.

CACNB1 expression relates to conditions like cardiac arrhythmia and skeletal muscle disorders. Changes in its expression or function can disrupt normal calcium ion balance and lead to these diseases. Interactions with proteins like CACNA1C which also plays a role in channel function are of particular interest as alterations in these proteins are often seen in these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulatory subunit of L-type calcium channels (PubMed : 1309651, PubMed : 15615847, PubMed : 8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed : 15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed : 1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed : 8107964).
See full target information CACNB1
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