Skip to main content

Rabbit Polyclonal CACNG1 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human CACNG1.

Be the first to review this product! Submit a review

Images

Western blot - Anti-CACNG1 antibody (AB135994), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Synthetic Peptide within Human CACNG1. The exact immunogen used to generate this antibody is proprietary information. Database link Q06432

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Predicted
Rat
Predicted

Tested
Tested

Species
Human
Dilution info
1/500.00000 - 1/1000.00000
Notes

-

Predicted
Predicted

Species
Mouse, Rat
Dilution info
-
Notes

-

Target data

Function

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.

Alternative names

CACNLG, CACNG1, Voltage-dependent calcium channel gamma-1 subunit

Recommended products

Rabbit Polyclonal CACNG1 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human CACNG1.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Synthetic Peptide within Human CACNG1. The exact immunogen used to generate this antibody is proprietary information. Database link Q06432
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

CACNG1 also known as gamma-1 subunit of the voltage-dependent calcium channel plays a critical role in calcium channel activity. Its molecular weight is approximately 28 kDa. The protein features prominently in skeletal muscle tissues. CACNG1 forms a part of the auxiliary subunits necessary for the proper function of the calcium channel complex influencing the biophysical properties of the channel as well as its trafficking to the cell surface.

Biological function summary

CACNG1 stabilizes the calcium channel complex in skeletal muscles influencing muscle contraction. It participates in modulating the gating properties of the L-type calcium channels by slowing the inactivation process. This subunit ensures the proper functioning of the calcium channels which are essential for excitation-contraction coupling in muscle. The interplay with other subunits in the calcium channel complex highlights its influence on neuromuscular transmission.

Pathways

CACNG1 plays a significant role in the calcium signaling and muscle contraction pathways. CACNG1 interacts closely with other subunits of the calcium channel like CACNA1S (alpha-1S) which serves as the core of the calcium channel complex. These pathways are critical in converting electrochemical signals into muscle contraction and rely on the precise action of the channel components to regulate calcium influx efficiently.

Associated diseases and disorders

Mutations or malfunctions in CACNG1 are associated with conditions affecting muscle function such as hypoPP (hypokalemic periodic paralysis) and MH (malignant hyperthermia). These muscle-related disorders often involve the misregulation of calcium channels linking CACNG1 to proteins like RYR1 (ryanodine receptor 1) involved in calcium release from the sarcoplasmic reticulum. Understanding CACNG1 and its interactions within these complex networks is essential for developing interventions and treatments for these conditions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Western blot - Anti-CACNG1 antibody (ab135994), expandable thumbnail

    Western blot - Anti-CACNG1 antibody (ab135994)

    All lanes: Western blot - Anti-CACNG1 antibody (ab135994) at 1/500 dilution

    All lanes: lysates from COLO205 cells at 30 µg

    Predicted band size: 25 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com