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AB135994

Anti-CACNG1 antibody

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(1 Publication)

Rabbit Polyclonal CACNG1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CACNG1.

View Alternative Names

CACNLG, CACNG1, Voltage-dependent calcium channel gamma-1 subunit

1 Images
Western blot - Anti-CACNG1 antibody (AB135994)
  • WB

Unknown

Western blot - Anti-CACNG1 antibody (AB135994)

All lanes:

Western blot - Anti-CACNG1 antibody (ab135994) at 1/500 dilution

All lanes:

lysates from COLO205 cells at 30 µg

Predicted band size: 25 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CACNG1. The exact immunogen used to generate this antibody is proprietary information.

Q06432

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CACNG1 also known as gamma-1 subunit of the voltage-dependent calcium channel plays a critical role in calcium channel activity. Its molecular weight is approximately 28 kDa. The protein features prominently in skeletal muscle tissues. CACNG1 forms a part of the auxiliary subunits necessary for the proper function of the calcium channel complex influencing the biophysical properties of the channel as well as its trafficking to the cell surface.
Biological function summary

CACNG1 stabilizes the calcium channel complex in skeletal muscles influencing muscle contraction. It participates in modulating the gating properties of the L-type calcium channels by slowing the inactivation process. This subunit ensures the proper functioning of the calcium channels which are essential for excitation-contraction coupling in muscle. The interplay with other subunits in the calcium channel complex highlights its influence on neuromuscular transmission.

Pathways

CACNG1 plays a significant role in the calcium signaling and muscle contraction pathways. CACNG1 interacts closely with other subunits of the calcium channel like CACNA1S (alpha-1S) which serves as the core of the calcium channel complex. These pathways are critical in converting electrochemical signals into muscle contraction and rely on the precise action of the channel components to regulate calcium influx efficiently.

Mutations or malfunctions in CACNG1 are associated with conditions affecting muscle function such as hypoPP (hypokalemic periodic paralysis) and MH (malignant hyperthermia). These muscle-related disorders often involve the misregulation of calcium channels linking CACNG1 to proteins like RYR1 (ryanodine receptor 1) involved in calcium release from the sarcoplasmic reticulum. Understanding CACNG1 and its interactions within these complex networks is essential for developing interventions and treatments for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
See full target information CACNG1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Platelets 31:853-859 PubMed31893963

2020

Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis.

Applications

Unspecified application

Species

Unspecified reactive species

Ejaife O Agbani,Xiaojuan Zhao,Christopher M Williams,Riyaad Aungraheeta,Ingeborg Hers,Erik R Swenson,Alastair W Poole
View all publications
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Product promise

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