AB134137

Anti-cadherin 10 antibody [EPR5115]

RabMAb
Recombinant
What is this?

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(3 Publications)

Rabbit Recombinant Monoclonal cadherin 10 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 3 publications.

View Alternative Names

Cadherin-10, T2-cadherin, CDH10

2 Images

Flow Cytometry (Intracellular) - Anti-cadherin 10 antibody [EPR5115] (AB134137)

Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - Anti-cadherin 10 antibody [EPR5115] (AB134137)

Intracellular flow cytometric analysis of permeabilised U-87 MG cells labelling cadherin 10 with ab134137 at 1/10 dilution (red) or rabbit IgG negative (green).

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Western blot - Anti-cadherin 10 antibody [EPR5115] (AB134137)

The expression profile observed is consistent with what has been described in the literature PMID : 16181616

All lanes:

Western blot - Anti-cadherin 10 antibody [EPR5115] (ab134137) at 1/1000 dilution

Lane 1:

Human fetal brain lysate at 10 µg

Lane 2:

U-87 MG lysate at 10 µg

Lane 3:

Human fetal lung lysate at 10 µg

Secondary

All lanes:

Goat Anti-rabbit HRP at 1/2000 dilution

Predicted band size: 88 kDa

Observed band size: 115-130 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR5115

Isotype

IgG

Carrier free

Reacts with

Human

Applications

Flow Cyt (Intra), WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10 - 1/100", "FlowCytIntra-species-notes": "<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody." }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cadherin-10 often referred to as CDH10 is a member of the classical cadherin family which are vital components of calcium-dependent cell-cell adhesion. This protein is approximately 98 kDa in mass. CDH10 is expressed widely in the central nervous system and is also present in other tissues such as the pancreas and kidney. The cadherin family plays a significant role in mediating homophilic interactions between cells influencing tissue architecture and integrity.

Biological function summary

Cadherin-10 assists in maintaining precise cellular recognition and adhesion. It is particularly involved in the development and maintenance of neural circuits suggesting its involvement in the complexity of brain network formation. Cadherin-10 operates as part of adhesion complexes interacting with cytoplasmic components that link to the actin cytoskeleton thereby influencing cell signaling pathways and cellular communication.

Pathways

Cadherin-10 contributes significantly to the Wnt signaling pathway and adherens junction pathways. These pathways are critical for processes such as cellular differentiation migration and organization. Cadherin-10 has related interactions with proteins like beta-catenin within these pathways which facilitates signal transduction and cell structural integrity.

Alterations in cadherin-10 can affect neurological and developmental conditions. Mutations or dysregulation of CDH10 have associations with autism spectrum disorders impacting neural communication genes. Similarly changes in cadherin-10 expressions also show connections to manic disorders implying a role in emotional regulation pathways linked to neuropsychiatric proteins such as N-cadherin and synaptic adhesion molecules.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

See full target information CDH10

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 15:3627-3642 PubMed40093901

2025

Circular RNA CHACR is involved in the pathogenesis of cardiac hypertrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Lili Chen,Wenjing Wang,Yiheng Zhao,Shuchen Zhang,Xiang Zhou

CNS neuroscience & therapeutics 31:e70257 PubMed39915908

2025

Caloric Restriction Preserves BBB Integrity After Transient Focal Cerebral Ischemia Through Reducing Neutrophil Infiltration.

Applications

Unspecified application

Species

Unspecified reactive species

Chenran Wang,Leilei Mao,Miao He,Jia Zhang,Yichen Huang,Yue Zhang,Jing Xu,Shaoqiang Huang,Yanqin Gao

The European journal of neuroscience 49:1436-1453 PubMed30589479

2019

A Sam68-dependent alternative splicing program shapes postsynaptic protein complexes.

Applications

Unspecified application

Species

Unspecified reactive species

Harald Witte,Dietmar Schreiner,Peter Scheiffele

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-cadherin 10 antibody [EPR5115]

Flow Cytometry (Intracellular) - Anti-cadherin 10 antibody [EPR5115] (AB134137)

Western blot - Anti-cadherin 10 antibody [EPR5115] (AB134137)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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Product promise