AB189965

Anti-Cadherin 7 antibody - N-terminal

Name: Anti-Cadherin 7 antibody - N-terminal (ab189965) | Abcam
Brand: Abcam Limited
SKU: AB189965

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(1 Publication)

Rabbit Polyclonal Cadherin 7 antibody. N-terminal. Suitable for WB, IHC-P, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CDH7 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CDH7L1, CDH7, Cadherin-7

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin 7 antibody - N-terminal (AB189965)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin 7 antibody - N-terminal (AB189965)

Immunohistochemistry of formalin-fixed, paraffin-embedded Human tonsil tissue labeling Cadherin 7 with ab189965 at 10 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin 7 antibody - N-terminal (AB189965)

Immunohistochemistry of formalin-fixed, paraffin-embedded Human prostata carcinoma tissue labeling Cadherin 7 with ab189965 at 10 μg/ml.

Flow Cytometry (Intracellular) - Anti-Cadherin 7 antibody - N-terminal (AB189965)

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-Cadherin 7 antibody - N-terminal (AB189965)

Intracellular Flow Cytometry ofanalysis NCI-H292 cells using ab189965 at a 1/10 dilution (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Supplier Data

Western blot - Anti-Cadherin 7 antibody - N-terminal (AB189965)

All lanes:

Western blot - Anti-Cadherin 7 antibody - N-terminal (ab189965) at 1/60 dilution

All lanes:

K562 cell lysate

Predicted band size: 87 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB, Flow Cyt (Intra)

applications

Immunogen

Synthetic Peptide within Human CDH7 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9ULB5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<a href='/en-us/products/primary-antibodies/rabbit-igg-polyclonal-isotype-control-chip-grade-ab171870'>ab171870</a> - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cadherin 7 also known as CDH7 is a member of the classical cadherin family involved in calcium-dependent cell-cell adhesion. The mass of Cadherin 7 is approximately 88 kDa. It is mostly expressed in the nervous system where it plays a role in the formation and maintenance of cellular structures essential for neural function. The protein comprises extracellular cadherin repeats a transmembrane domain and a highly conserved cytoplasmic tail which allows it to facilitate homophilic interactions between cells.

Biological function summary

This protein mediates strong stable adhesion among cells in the neural tissue. It is integral to the assembly of adherens junctions where it participates in cell signaling and structural integrity. Cadherin 7 does not function alone; it often forms complexes with cytoplasmic proteins such as catenins which link the cadherin to the actin cytoskeleton providing mechanical support and facilitating intracellular signaling.

Pathways

Cadherin 7 plays a critical role in pathways like the cadherin-catenin complex and the Wnt signaling pathway. The cadherin-catenin complex pathway modulates cell polarity and gene expression by interacting with proteins like β-catenin. In the Wnt signaling pathway Cadherin 7 helps regulate cell fate proliferation and migration which are all vital for neural development and tissue homeostasis.

Cadherin 7 has implications in neurological conditions such as schizophrenia and autism spectrum disorders. Disruptions in its function may affect neural cell adhesion and signaling leading to these conditions. Additionally altered expression of Cadherin 7 in association with changes in other proteins like N-cadherin has been observed in cancer metastasis highlighting its importance in cell adhesion and signaling in both neural and cancer contexts.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

See full target information CDH7

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 14:2268-2286 PubMed35255005

2022

A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1.

Applications

Unspecified application

Species

Unspecified reactive species

Xiwu Ouyang,Lemeng Feng,Lei Yao,Jingyu Zhang,Yao Xiao,Guodong Liu,Gewen Zhang,Zhiming Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Cadherin 7 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin 7 antibody - N-terminal (AB189965)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin 7 antibody - N-terminal (AB189965)

Flow Cytometry (Intracellular) - Anti-Cadherin 7 antibody - N-terminal (AB189965)

Western blot - Anti-Cadherin 7 antibody - N-terminal (AB189965)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise