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AB131135

Anti-Cadherin like 23 antibody

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(2 Publications)

Rabbit Polyclonal Cadherin like 23 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications.

View Alternative Names

KIAA1774, KIAA1812, UNQ1894/PRO4340, CDH23, Cadherin-23, Otocadherin

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin like 23 antibody (AB131135)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin like 23 antibody (AB131135)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labelling Cadherin like 23 with ab131135 at 1/100 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-Cadherin like 23 antibody (AB131135)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Cadherin like 23 antibody (AB131135)

Immunofluorescence analysis of HeLa cells labelling Cadherin like 23 with ab131135 at 1/100 dilution. The picture on the right is treated with immunising peptide.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Secondary Antibodies

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Primary Antibodies

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Anti-Myosin VIIa/MYO7A antibody [EPR7497]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cadherin like 23 also known as CDH23 or otocadherin is a protein with a mass of approximately 335 kDa. This protein is a member of the cadherin superfamily and acts mechanically to mediate calcium-dependent cell-cell adhesion. It is important for maintaining the structure and function of hair cells in the inner ear where it is highly expressed. Additionally CDH23 is present in other tissues such as the retina highlighting its role in sensory organs.
Biological function summary

Cadherin like 23 contributes to the organization and maintenance of stereocilia which are actin-filled protrusions important for mechanotransduction in cochlear hair cells. CDH23 forms part of the tip link complex that connects stereocilia enabling the conversion of mechanical stimuli into electrical signals. Its involvement in forming this complex illustrates its essential role in auditory function and cellular communication.

Pathways

Cadherin like 23 is involved in essential biological processes linked to calcium signaling and the auditory transduction pathway. It interacts with other proteins such as myosin VIIA and protocadherin 15 which are critical for hair cell function and hearing. The protein plays a role in the mechanotransduction channel activity contributing to the regulation of ion influx that triggers auditory perception.

Mutational defects in Cadherin like 23 have been associated with Usher syndrome type 1D and non-syndromic sensorineural deafness (DFNB12). CDH23 mutations lead to disrupted hair cell function resulting in hearing loss and balance disorders frequently seen in these conditions. The protein's connection to disease also involves another cadherin-related protein protocadherin 15 which shares overlapping roles in similar cellular pathways highlighting the intricate interplay of these proteins in auditory-related genetic disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
See full target information CDH23
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer biology & therapy 23:150-162 PubMed35130111

2022

The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Wang,Xiaowan Zhou,Zengli Guo,Nan Huang,Juan Li,Yanfang Lv,Lulu Han,Wei Zheng,Dandan Xu,Dafei Chai,Huizhong Li,Liantao Li,Junnian Zheng

International journal of molecular sciences 23: PubMed35163494

2022

Usher Syndrome Belongs to the Genetic Diseases Associated with Radiosensitivity: Influence of the ATM Protein Kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Joëlle Al-Choboq,Mélanie L Ferlazzo,Laurène Sonzogni,Adeline Granzotto,Laura El-Nachef,Mira Maalouf,Elise Berthel,Nicolas Foray
View all publications
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Product promise

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