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AB231662

Anti-CALCB antibody

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Rabbit Polyclonal CALCB antibody. Suitable for WB, IHC-P and reacts with Rat samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Calcb.

View Alternative Names

Calcitonin gene-related peptide 2, CGRP2, Beta-type CGRP, Calcitonin gene-related peptide II, CGRP-II, Calcb

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALCB antibody (AB231662)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALCB antibody (AB231662)

Formalin-fixed, paraffin-embedded rat liver tissue stained for CALCB using ab231662 at 20 μg/ml in immunohistochemical analysis.

Western blot - Anti-CALCB antibody (AB231662)
  • WB

Supplier Data

Western blot - Anti-CALCB antibody (AB231662)

All lanes:

Western blot - Anti-CALCB antibody (ab231662) at 2 µg/mL

All lanes:

Rat serum

Predicted band size: 14 kDa

false

Western blot - Anti-CALCB antibody (AB231662)
  • WB

Supplier Data

Western blot - Anti-CALCB antibody (AB231662)

All lanes:

Western blot - Anti-CALCB antibody (ab231662) at 2 µg/mL

All lanes:

Recombinant rat CALCB protein

Predicted band size: 14 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Rat Calcb.

P10093

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab231662 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 55.77% Glycerol (glycerin, glycerine), 44.12% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CALCB also known as calcitonin gene-related peptide beta (CGRP-beta) is a peptide with a molecular mass of about 12 kDa. It is a member of the calcitonin family of proteins. This peptide is expressed mainly in the central and peripheral nervous systems where it acts as a neurotransmitter and neuromodulator. CALCB has significant roles in neuronal communication and one can find it distributed in sensory neurons including the trigeminal ganglion.
Biological function summary

The peptide CGRP-beta plays a role in vasodilation which is the widening of blood vessels. It achieves this by signaling endothelial cells to increase cyclic AMP and relax smooth muscle cells in blood vessel walls. Although CALCB does not form part of a larger complex its action significantly influences vascular tone and blood flow. As such the peptide functions in the regulation of cardiovascular homeostasis and pain transmission.

Pathways

CGRP-beta is an important element in the calcitonin gene-related peptide pathway and this affects vasodilation and pain mechanisms. It interacts closely with proteins such as the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs) which together form the receptor complex mediating its effects. The signaling pathway is also intertwined with pathways affecting the release of other neurotransmitters and inflammatory mediators.

CGRP-beta is highly relevant in understanding migraines and cardiovascular diseases. Elevated levels of this peptide are often associated with migraine attacks as it contributes to the dilation of cerebral blood vessels. The target is also investigated in the context of hypertension where its modulation of vascular tone might be disrupted. In such conditions alterations in CGRP-beta interaction with other proteins like its receptor components CRLR and RAMPs become significant in pathophysiology studies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

CALCB/CGRP2 is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
See full target information Calcb
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