AB140131

Anti-Calcipressin 1/RCAN1 antibody [EPR8911]

Name: Anti-Calcipressin 1/RCAN1 antibody [EPR8911] (ab140131) | Abcam
Brand: Abcam Limited
SKU: AB140131
Price: 390 USD
Availability: InStock
Rating: 3 (1 reviews)

RabMAb
Recombinant
What is this?

(1 Review)

(6 Publications)

Rabbit Recombinant Monoclonal Calcipressin 1/RCAN1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications.

View Alternative Names

ADAPT78, CSP1, DSC1, DSCR1, RCAN1, Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, Regulator of calcineurin 1, MCIP1

1 Images

Unknown

Western blot - Anti-Calcipressin 1/RCAN1 antibody [EPR8911] (AB140131)

All lanes:

Western blot - Anti-Calcipressin 1/RCAN1 antibody [EPR8911] (ab140131) at 1/10000 dilution

All lanes:

Human fetal heart lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 28 kDa

false

Carrier free

Anti-Calcipressin 1/RCAN1 antibody [EPR8911] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR8911

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Calcipressin 1 also known as RCAN1 is a protein that plays a central role in regulating calcineurin activity. This protein weighs around 29-31 kDa. It is found in various human tissues especially in the heart brain and skeletal muscle. By binding to calcineurin RCAN1 inhibits its phosphatase activity influencing cellular pathways that rely on calcium signaling.

Biological function summary

Within the cell RCAN1 functions as a modulator of calcineurin-dependent transcriptional activity. It interacts with several proteins including those in the signaling complex linked to the NFAT (nuclear factor of activated T-cells). By managing the activity of calcineurin RCAN1 influences the transcription of genes involved in growth development and immune responses. Therefore its role is critical in maintaining cellular homeostasis and response to changes in calcium levels.

Pathways

RCAN1 impacts the calcineurin-NFAT signaling and MAPK (mitogen-activated protein kinase) pathways. In the calcineurin-NFAT pathway RCAN1 influences T-cell activation and the immune response by modulating NFAT's transcriptional activity. Moreover the MAPK pathway which is important for cell proliferation and differentiation sees regulation through RCAN1's action on calcineurin interfacing with kinases like JNK (c-Jun N-terminal kinase) to adjust signaling outputs.

Alterations in RCAN1 expression or function associate with Down syndrome and Alzheimer's disease. Increased RCAN1 levels often seen in Down syndrome lead to reduced calcineurin function affecting neuronal signaling pathways. In Alzheimer's disease the interaction with proteins like Tau contributes to neurodegenerative processes. Understanding RCAN1's involvement provides insights into potential therapeutic targets for these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed : 12809556). Could play a role during central nervous system development (By similarity).

See full target information RCAN1

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastroenterology 31:105554 PubMed40495950

2025

Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/ mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Shi-Yi Lyu,Wang Xiao,Yan-Jing Chen,Qiu-Ling Liao,Ye-Yu Cai,Cheng Yu,Jia-Yi Liu,Huan Liu,Min-Ping Zhang,Yu-Lu Ren,Qi-Ling Yu,Yi-Ming Qi,En-Hua Xiao,Yong-Heng Luo

Cell death & disease 15:406 PubMed38858351

2024

Histone acetyltransferase Kat2a regulates ferroptosis via enhancing Tfrc and Hmox1 expression in diabetic cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Zhen,Xia Sheng,Tianlong Chen,Haitao Yu

Cells 11: PubMed36429004

2022

Overexpression of , a Gene on Human Chromosome , Alters Cell Redox and Mitochondrial Function in Enamel Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Li,Veronica Costiniti,Guilherme H Souza Bomfim,Maria Neginskaya,Ga-Yeon Son,Beverly Rothermel,Evgeny Pavlov,Rodrigo S Lacruz

Journal of bone oncology 30:100383 PubMed34336566

2021

RCAN1.4 suppresses the osteosarcoma growth and metastasis via interfering with the calcineurin/NFAT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Bao Huang,Zenghui Jiang,Saishuang Wu,Hao Wu,Xuyang Zhang,Jian Chen,Fengdong Zhao,Junhui Liu

Experimental & molecular medicine 52:865-875 PubMed32467610

2020

The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs.

Applications

Unspecified application

Species

Unspecified reactive species

Bao Huang,Yongqing He,Shengwen Li,Xiaoan Wei,Junhui Liu,Zhi Shan,Yue Huang,Jian Chen,Fengdong Zhao

Physiological reports 6:e13912 PubMed30430766

2018

Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia Rouet-Benzineb,Régine Merval,Evelyne Polidano

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Calcipressin 1/RCAN1 antibody [EPR8911]

Western blot - Anti-Calcipressin 1/RCAN1 antibody [EPR8911] (AB140131)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

Product promise