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AB103422

Anti-Calcitonin receptor/CT-R antibody

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(1 Publication)

Rabbit Polyclonal Calcitonin receptor/CT-R antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CALCR.

View Alternative Names

Calcitonin receptor, CT-R, CALCR

2 Images
Western blot - Anti-Calcitonin receptor/CT-R antibody (AB103422)
  • WB

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Western blot - Anti-Calcitonin receptor/CT-R antibody (AB103422)

All lanes:

Western blot - Anti-Calcitonin receptor/CT-R antibody (ab103422) at 5 µg/mL

All lanes:

Human kidney tissue lysate at 50 µg

Predicted band size: 55 kDa

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Western blot - Anti-Calcitonin receptor/CT-R antibody (AB103422)
  • WB

Unknown

Western blot - Anti-Calcitonin receptor/CT-R antibody (AB103422)

All lanes:

Western blot - Anti-Calcitonin receptor/CT-R antibody (ab103422) at 5 µg/mL

Lane 1:

Calcitonin receptor/CT-R transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Predicted band size: 55 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CALCR.

P30988

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Calcitonin receptor (CT-R) is a protein that mechanically binds calcitonin a hormone involved in regulating calcium levels. Another known name is Salmon Calcitonin Receptor. The receptor has a mass approximately 70 kDa and is expressed in various tissues including kidney osteoclasts and the central nervous system. The receptor is a critical part of calcium-phosphate homeostasis facilitating the actions of calcitonin across different physiological systems in the body.
Biological function summary

CT-R serves a significant role in bone metabolism and mineral homeostasis. It participates in the inhibition of osteoclast-mediated bone resorption which is an important process in maintaining bone density. Although CT-R functions independently interactions with other hormones like parathyroid hormone and vitamin D highlight its importance in a larger network of bone health. The receptor contributes to reducing blood calcium levels by decreasing calcium release from bones and enhancing renal calcium excretion.

Pathways

CT-R is actively involved in the cyclic adenosine monophosphate (cAMP) and phosphoinositide signaling pathways essential for mediating cellular responses. Through these pathways CT-R closely associates with the related protein Calcitonin Gene-Related Peptide (CGRP) which shares some signaling components and effects on targeted cells. These pathways highlight the mechanistic basis for CT-R's roles in regulating calcium and phosphate metabolism.

CT-R has connections to osteoporosis and paget's disease. These conditions involve impaired bone metabolism where CT-R activity—or lack of activity—contributes to pathogenesis. The receptor's relationship with the proteins parathyroid hormone and CGRP suggests its indirect involvement in disease progression since these proteins also modulate bone health and are potential therapeutic targets for treating such bone disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed : 35324283, PubMed : 38603770). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively (PubMed : 35324283, PubMed : 38603770). IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes (PubMed : 35324283, PubMed : 38603770). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed : 35324283, PubMed : 7476993).. Isoform 2. Non-functional protein. Unable to couple to G proteins and activate adenylyl cyclase (PubMed : 7476993). Does not undergo receptor internalization following ligand binding (PubMed : 7476993).
See full target information CALCR
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of reproduction and development 60:317-23 PubMed24899099

2014

The effects of calcitonin on the development of and Ca2+ levels in heat-shocked bovine preimplantation embryos in vitro.

Applications

WB

Species

Cow

Shumpei Kamano,Shuntaro Ikeda,Miki Sugimoto,Shinichi Kume
View all publications
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