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AB238110

Anti-Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 antibody

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(3 Publications)

Rabbit Polyclonal Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CACNA2D1 aa 500 to C-terminus.

View Alternative Names

CACNL2A, CCHL2A, MHS3, CACNA2D1, Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 antibody (AB238110)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 antibody (AB238110)

Paraffin-embedded human skeletal muscle tissue stained for Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 with ab238110 at a 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 antibody (AB238110)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Calcium channel L type DHPR alpha 2 subunit/CACNA2D1 antibody (AB238110)

Immunocytochemistry/ Immunofluorescence of HeLa cells with ab238110 1/200 counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CACNA2D1 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P54289

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Calcium channel L type DHPR alpha 2 subunit also known as CACNA2D1 or alpha-2-delta plays a significant role in cellular calcium regulation. This subunit typically part of the voltage-gated calcium channel complex allows calcium ions to enter the cells following electrical stimuli. With a mass of about 150 kDa CACNA2D1 expresses predominantly in skeletal and cardiac muscle tissues and the central nervous system. Its presence across different tissues suggests various physiological roles linking its mechanical function to electrical signaling and muscle contraction.
Biological function summary

CACNA2D1 aids in modulating neurotransmitter release and excitation-contraction coupling. This protein often integrates into the larger voltage-gated calcium channel complex working in concert with other subunits to optimize calcium flow. This particular function supports critical processes in muscle cells and neurons integrating signals in response to electrical impulses. The alpha-2-delta ligand poses significance here as well often used to modify the channel's activity and study its role in cellular communication.

Pathways

CACNA2D1 actively participates in electrical signaling and muscle contraction pathways. It contributes to the excitation-contraction coupling pathway in muscle cells aligning closely with proteins like the ryanodine receptor ensuring efficient calcium-induced calcium release. Its action also extends to the neurotransmitter release pathway where it associates with synaptic proteins regulating neurotransmission. The function within these pathways underlines its importance in both muscle and neural activities.

CACNA2D1 associates with conditions such as epilepsy and neuropathic pain. The dysfunction in its channel activity can lead to altered calcium flow contributing to these disorders. The alpha-2-delta ligand such as the gabapentin chemical structure plays a role here often targeting the channel to mitigate symptoms. Gabapentin's influence highlights the therapeutic potential of targeting CACNA2D1 in disease management providing critical insights into neuromodulation treatments.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (PubMed : 35293990). Plays an important role in excitation-contraction coupling (By similarity).
See full target information CACNA2D1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cardiovascular therapeutics 2024:7053116 PubMed39742020

2025

Overexpression of TRPV6 Inhibits Coronary Atherosclerosis-Related Inflammatory Response and Cell Apoptosis via the PKA/UCP2 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zheng,Huiying Zhang,Xuewen Li

Nature communications 14:6963 PubMed37907455

2023

Self-promoted electroactive biomimetic mineralized scaffolds for bacteria-infected bone regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Zixin Li,Danqing He,Bowen Guo,Zekun Wang,Huajie Yu,Yu Wang,Shanshan Jin,Min Yu,Lisha Zhu,Liyuan Chen,Chengye Ding,Xiaolan Wu,Tianhao Wu,Shiqiang Gong,Jing Mao,Yanheng Zhou,Dan Luo,Yan Liu

Frontiers in integrative neuroscience 16:855071 PubMed35669734

2022

Validation of Functional Connectivity of Engineered Neuromuscular Junction With Recombinant Monosynaptic Pseudotyped ΔG-Rabies Virus Tracing.

Applications

Unspecified application

Species

Unspecified reactive species

Ulrich Stefan Bauer,Vegard Fiskum,Rajeevkumar Raveendran Nair,Rosanne van de Wijdeven,Clifford Kentros,Ioanna Sandvig,Axel Sandvig
View all publications
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Product promise

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