Anti-calcyphosine antibody [EPR15631] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Calcyphosine also known as CAPS is a calcium-binding protein with a molecular mass of approximately 22 kDa. It plays a role in intracellular calcium signaling. Calcyphosine expression occurs widely in multiple tissues with high levels observed in the thyroid gland and epithelial tissues. It binds calcium ions impacting cellular processes such as signal transduction and cell communication.

Biological function summary

Calcyphosine influences several cellular functions related to calcium homeostasis and signaling. It does not form part of any larger complex but modulates cellular activities by regulating calcium ion concentrations inside cells. This regulation is critical for functions like muscle contraction hormone secretion and neurotransmitter release. Its presence in different tissues suggests diverse roles depending on the cellular environment.

Pathways

Calcyphosine plays a role in calcium-dependent pathways significant for maintaining cellular activities. It intersects with the calcium signaling pathway affecting proteins like calmodulin and calcineurin which further mediate various cellular responses. These interactions alter signal transmission processes vital for cell responses and adaptations.

Associated diseases and disorders

Studies have noted calcyphosine's involvement in thyroid-related conditions and some cancers. Altered expression levels link the protein to thyroid disorders potentially affecting thyroid hormone production and regulation. Calcyphosine's interaction with proteins like TSH receptor and thyroid transcription factors highlights its role in thyroid function and its potential influence on thyroid pathology and neoplastic conditions.