AB230240

Anti-CALML3 antibody

Name: Anti-CALML3 antibody (ab230240) | Abcam
Brand: Abcam Limited
SKU: AB230240

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(1 Publication)

Rabbit Polyclonal CALML3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Calmodulin-like protein 3.

View Alternative Names

Calmodulin-like protein 3, CaM-like protein, Calmodulin-related protein NB-1, CLP, CALML3

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALML3 antibody (AB230240)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALML3 antibody (AB230240)

Paraffin-embedded human skin tissue stained for CALML3 using ab230240 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALML3 antibody (AB230240)

Paraffin-embedded human cervical cancer tissue stained for CALML3 using ab230240 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-CALML3 antibody (AB230240)

All lanes:

Western blot - Anti-CALML3 antibody (ab230240) at 1/1000 dilution

All lanes:

A431 (human epidermoid carcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 17 kDa

Observed band size: 17 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Calmodulin-like protein 3.

P27482

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CALML3 also known as Calmodulin-like protein 3 is part of the calmodulin protein family. This protein has a molecular mass of approximately 15 kDa. It mainly expresses in epithelial tissues including the epidermis. CALML3 has a role similar to calmodulin but differs in specific expression patterns and functional specificity. In cellular contexts it functions by binding calcium ions which induces a conformational change necessary for its interactions with target proteins.

Biological function summary

CALML3 regulates various cellular processes involving calcium signaling. It does this without forming a dinstinct multi-protein complex. This regulation influences cell cycle progression and cell differentiation within tissues where CALML3 is present. By modulating calcium-dependent pathways CALML3 contributes to maintaining cellular homeostasis. The calcium binding attribute of CALML3 allows it to modulate enzymes ion channels and other proteins relevant to its locality of expression.

Pathways

CALML3 plays a significant role in calcium signaling pathways influencing various other cellular pathways such as apoptosis. CALML3 interacts with pathways linked to epidermal growth and differentiation. In these processes CALML3 shares functional relationships with proteins such as calmodulin and other calmodulin-like proteins contributing to downstream signaling processes.

CALML3 has correlations with cancer and skin disorders. Changes in CALML3 expression levels can relate to tumorigenesis particularly in cancers originating from epithelial tissues. For instance altered CALML3 expression can affect signaling pathways involved in cell proliferation. CALML3 may interact with other proteins such as CaMKs (Ca2+/calmodulin-dependent protein kinase) in the context of these disorders implicating it in disease-specific signaling alterations.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.

See full target information Calmodulin-like protein 3

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:105745 PubMed36590171

2023

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4.

Applications

Unspecified application

Species

Unspecified reactive species

Chenggang Zhang,Xianxiong Ma,Guanxin Wei,Xiuxian Zhu,Peng Hu,Xiang Chen,Dianshi Wang,Yuan Li,Tuo Ruan,Weikang Zhang,Kaixiong Tao,Chuanqing Wu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CALML3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALML3 antibody (AB230240)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CALML3 antibody (AB230240)

Western blot - Anti-CALML3 antibody (AB230240)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise