Rabbit Polyclonal CALML5 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Calmodulin-like protein 5 aa 1 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
IHC-P | WB | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes Alternatively Tris-EDTA buffer (pH8.0) may be used. Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Select an associated product type
Binds calcium. May be involved in terminal differentiation of keratinocytes.
CLSP, CLSP, CALML5, Calmodulin-like protein 5, Calmodulin-like skin protein
Rabbit Polyclonal CALML5 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Calmodulin-like protein 5 aa 1 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
CALML5 also known as calmodulin-like protein 5 is a small calcium-binding protein with a molecular weight of approximately 15 kDa. It shares structural similarities with calmodulin but has a distinct expression pattern. This protein is strongly expressed in keratinocytes particularly in the epidermis and is involved in the calcium-mediated signaling processes that regulate skin cell function and differentiation.
CALML5 modulates processes involved in epidermal homeostasis and repair. It plays an important role in the regulation of keratinocyte differentiation an essential process for proper skin barrier function. CALML5 does not form part of a large molecular complex but interacts with other calcium-binding proteins to influence epidermal physiology.
CALML5 is integrated into the calcium signaling pathway which is critical for calcium-dependent regulation of keratinocyte activity. It relates closely to other proteins within this pathway such as calcium-binding proteins like calmodulin. Its activity is important in relaying calcium signals that influence cellular processes like cell proliferation and differentiation.
CALML5 has links to skin conditions such as psoriasis and certain types of dermatitis where epidermal differentiation is disrupted. CALML5 may interact with proteins such as keratin to influence these disease processes highlighting its potential role in the maintenance of epidermal health and integrity. Understanding its functions could lead to new therapeutic strategies for managing skin-related disorders.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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15% SDS PAGE
All lanes: Western blot - Anti-CALML5 antibody (ab154631) at 1/1000 dilution
All lanes: A431 whole cell lysate at 30 µg
Predicted band size: 16 kDa
Immunohistochemical analysis of paraffin-embedded Human hepatoma tissue, labeling CALML5 with ab154631 at 1/500 dilution.
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