AB236590

Anti-CAP2 antibody

Name: Anti-CAP2 antibody (ab236590) | Abcam
Brand: Abcam Limited
SKU: AB236590

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(4 Publications)

Rabbit Polyclonal CAP2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Adenylyl cyclase-associated protein 2 aa 200-500.

View Alternative Names

Adenylyl cyclase-associated protein 2, CAP 2, CAP2

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

Paraffin-embedded human heart tissue stained for CAP2 with ab236590 at a 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

Paraffin-embedded human skeletal muscle tissue stained for CAP2 with ab236590 at a 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-CAP2 antibody (AB236590)

All lanes:

Western blot - Anti-CAP2 antibody (ab236590) at 1/1000 dilution

Lane 1:

HepG2 (human liver hepatocellular carcinoma cell line) cell lysate

Lane 2:

Mouse muscle tissue lysate

Lane 3:

Mouse gonadal tissue lysate

Lane 4:

HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 53 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Adenylyl cyclase-associated protein 2 aa 200-500. The exact immunogen used to generate this antibody is proprietary information.

P40123

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity >95%.

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CAP2 also known as Cyclase Associated Protein 2 is a protein playing an essential role in actin dynamics. It has a molecular mass of approximately 54 kDa. Researchers have detected its expression in various tissues including the heart skeletal muscle and brain. CAP2 influences the organization of the cytoskeleton by binding to actin filaments and regulating their polymerization and depolymerization. Its activity makes it an important player in cell motility and structure maintenance.

Biological function summary

CAP2 contributes to cellular processes by modulating actin filament turnover and facilitating actin recycling. It operates as part of a protein complex that includes other actin-binding proteins often working in tandem with profilin and cofilin. This complex formation is integral to the regulation of cytoskeletal organization impacting important cellular functions like cell division intracellular transport and signal transduction.

Pathways

CAP2 is an active participant in pathways controlling cell movement and structural integrity particularly the actin cytoskeleton signaling pathway. In this role CAP2 interacts with proteins such as cofilin which also modulates actin dynamics to maintain a balance of actin filament assembly and disassembly. Another pathway CAP2 is involved in is the cell adhesion pathway where it helps facilitate the dynamic remodeling necessary for cell attachment and migration.

CAP2 has been linked to cardiac diseases and cancer. Alterations in CAP2 expression have been associated with the development of dilated cardiomyopathy a condition marked by weakened heart muscle functionality. Furthermore CAP2 has demonstrated interactions with p53 a protein often mutated in cancers implicating it in processes that may contribute to tumor growth and metastasis. These connections reveal its importance not only in normal cellular function but also in pathological states.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Involved in the regulation of actin polymerization.

See full target information Adenylyl cyclase-associated protein 2

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Discover oncology 16:1253 PubMed40601174

2025

Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Jian,Nana Hu,Rong He,Le He,He Xiao,Xingqiao Peng,Yang Peng,Yuxin Yang,Xiaoyan Dai,Dong Wang,Yan Feng,Nan Dai,Qian Chen

International journal of molecular medicine 48: PubMed34414454

2021

MicroRNA‑28‑3p inhibits angiotensin‑converting enzyme 2 ectodomain shedding in 293T cells treated with the spike protein of severe acute respiratory syndrome coronavirus 2 by targeting A disintegrin and metalloproteinase 17.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Xu,Yi Li

Journal of gastrointestinal oncology 12:268-277 PubMed34012625

2021

CAP2 contributes to tumorigenesis in gastric cancer by targeting transcription factor SOX9.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Wan,Shengkui Qiu,Lei Yin,Xuesong Gao,Yasu Jiang,Shichun Feng,Chong Tang

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 39:1052-1058 PubMed31640951

2019

[Association of adenylate cyclase-associated protein 2 expression with histopathology and long-term prognosis of gastric cancer].

Applications

Unspecified application

Species

Unspecified reactive species

Sitang Ge,Shan Wang,Wujun Xiang,Lili Wang,Yuke Zhu,Xiang Zhu,Xun Wang,Lugen Zuo,Congqiao Jiang,Siqing Li,Mulin Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CAP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

Western blot - Anti-CAP2 antibody (AB236590)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise