Rabbit Recombinant Monoclonal CAPS2 antibody. Carrier free. Suitable for sELISA and reacts with Human, Mouse samples.
pH: 7.2 - 7.4
Constituents: 100% PBS
| sELISA | |
|---|---|
| Human | Expected |
| Mouse | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).
Cadps2
CAPS2, KIAA1591, CADPS2, Calcium-dependent secretion activator 2, Calcium-dependent activator protein for secretion 2, CAPS-2
Rabbit Recombinant Monoclonal CAPS2 antibody. Carrier free. Suitable for sELISA and reacts with Human, Mouse samples.
pH: 7.2 - 7.4
Constituents: 100% PBS
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.
This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
CAPS2 also known as Calcium-Dependent Secretion Activator 2 is a protein that facilitates the release of neuropeptides and hormones by enhancing dense core vesicle exocytosis. The molecular mass of CAPS2 is approximately 145 kDa. It is expressed mainly in the brain including areas such as the cerebellum and hippocampus. CAPS2 acts by interacting with SNARE proteins which are essential for vesicle fusion and release processes at synaptic sites.
The protein CAPS2 plays an important role in synaptic transmission and the regulation of neurotransmitter secretion. It promotes the priming and fusion of vesicles allowing their contents to be released into the synaptic cleft. CAPS2 is often linked with other synaptic and regulatory proteins within a protein complex that orchestrates the efficient release of neurotransmitters and neuropeptides necessary for proper neuronal signaling.
CAPS2 takes part in the secretory pathway critical for synaptic activity and signaling in neurons. It interacts with important proteins such as synaptotagmin and Munc13 which are involved in the regulation of vesicle priming and exocytosis. Moreover CAPS2 is implicated in the calcium-dependent pathways that regulate neurotransmitter release enhancing functional communication between neurons.
CAPS2 has been associated with autism spectrum disorders and schizophrenia. Studies indicate altered expression of CAPS2 may disrupt synaptic function potentially leading to these neurological conditions. The protein also interacts with voltage-gated calcium channels which are important for neuronal communication and are often involved in the pathophysiology of these disorders. Understanding CAPS2's involvement in these conditions offers potential targets for therapeutic intervention.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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