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AB307457

Anti-CAPS2 antibody [EPR27004-83] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal CAPS2 antibody. Carrier free. Suitable for sELISA and reacts with Human, Mouse samples.

View Alternative Names

CAPS2, KIAA1591, CADPS2, Calcium-dependent secretion activator 2, Calcium-dependent activator protein for secretion 2, CAPS-2

1 Images
Sandwich ELISA - Anti-CAPS2 antibody [EPR27004-83] - BSA and Azide free (Detector) (AB307457)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-CAPS2 antibody [EPR27004-83] - BSA and Azide free (Detector) (AB307457)

Sandwich ELISA of ab307455 with the capture antibody dilution at 2 µg/mL and detector antibody dilution at 0.5 µg/mL.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR27004-83

Isotype

IgG

Carrier free

Yes

Reacts with

Human, Mouse

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CAPS2 also known as Calcium-Dependent Secretion Activator 2 is a protein that facilitates the release of neuropeptides and hormones by enhancing dense core vesicle exocytosis. The molecular mass of CAPS2 is approximately 145 kDa. It is expressed mainly in the brain including areas such as the cerebellum and hippocampus. CAPS2 acts by interacting with SNARE proteins which are essential for vesicle fusion and release processes at synaptic sites.
Biological function summary

The protein CAPS2 plays an important role in synaptic transmission and the regulation of neurotransmitter secretion. It promotes the priming and fusion of vesicles allowing their contents to be released into the synaptic cleft. CAPS2 is often linked with other synaptic and regulatory proteins within a protein complex that orchestrates the efficient release of neurotransmitters and neuropeptides necessary for proper neuronal signaling.

Pathways

CAPS2 takes part in the secretory pathway critical for synaptic activity and signaling in neurons. It interacts with important proteins such as synaptotagmin and Munc13 which are involved in the regulation of vesicle priming and exocytosis. Moreover CAPS2 is implicated in the calcium-dependent pathways that regulate neurotransmitter release enhancing functional communication between neurons.

CAPS2 has been associated with autism spectrum disorders and schizophrenia. Studies indicate altered expression of CAPS2 may disrupt synaptic function potentially leading to these neurological conditions. The protein also interacts with voltage-gated calcium channels which are important for neuronal communication and are often involved in the pathophysiology of these disorders. Understanding CAPS2's involvement in these conditions offers potential targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).
See full target information CADPS2
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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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