Rabbit Polyclonal carabin antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TBC1D10C aa 1-200.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human TBC1D10C aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IV04
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Cow | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
Alternative names
Carabin, TBC1 domain family member 10C, TBC1D10C
Recommended products
Rabbit Polyclonal carabin antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TBC1D10C aa 1-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human TBC1D10C aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IV04
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Carabin also known as TBC1D10C functions as a signaling protein involved in the regulation of T-cell activation and calcium signaling. It has a molecular mass of approximately 40 kDa. This protein is expressed across various tissues with significant expression in immune system cells such as T-cells. Carabin interacts with other proteins within cells to control processes that are vital for maintaining proper immune responses.
- Biological function summary
Carabin acts as a negative regulator for the calcineurin-NFAT signaling pathway helping to control immune cell activation. It binds to calcineurin inhibiting its phosphatase activity which in turn reduces NFAT transcription factor activation. Carabin forms part of complexes within cells including those involving proteins like Ras which further modulates its regulatory functions. These interactions place carabin as an important protein in the context of immune system modulation and response.
- Pathways
Carabin participates in T-cell receptor (TCR) signaling and calcium signaling pathways. The interaction with calcineurin links carabin to the regulation of the immune response especially in T-cell signaling and activation. It relates to proteins such as NFAT and Ras coordinating responses that control the transcription of genes important for immune cell function. This positioning in pathways highlights carabin's role in ensuring immune homeostasis.
- Associated diseases and disorders
Carabin's malfunction or dysregulation can impact immune-related conditions including autoimmune diseases and immunodeficiencies. Alterations in carabin expression or activity have connections to increased risk of autoimmune disorders where the immune system misfires against the body's own cells. Carabin's interactions with proteins like calcineurin and NFAT are important in understanding immune imbalance which could guide therapeutic strategies for such conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-carabin antibody (ab127694)
10% SDS PAGE
All lanes: Western blot - Anti-carabin antibody (ab127694) at 1/500 dilution
All lanes: A431 whole cell lysate at 30 µg
Predicted band size: 39 kDa, 44 kDa, 50 kDa
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