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AB127694

Anti-carabin antibody

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(1 Publication)

Rabbit Polyclonal carabin antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TBC1D10C aa 1-200.

View Alternative Names

Carabin, TBC1 domain family member 10C, TBC1D10C

1 Images
Western blot - Anti-carabin antibody (AB127694)
  • WB

Unknown

Western blot - Anti-carabin antibody (AB127694)

10% SDS PAGE

All lanes:

Western blot - Anti-carabin antibody (ab127694) at 1/500 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 39 kDa,44 kDa,50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human TBC1D10C aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q8IV04

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Carabin also known as TBC1D10C functions as a signaling protein involved in the regulation of T-cell activation and calcium signaling. It has a molecular mass of approximately 40 kDa. This protein is expressed across various tissues with significant expression in immune system cells such as T-cells. Carabin interacts with other proteins within cells to control processes that are vital for maintaining proper immune responses.
Biological function summary

Carabin acts as a negative regulator for the calcineurin-NFAT signaling pathway helping to control immune cell activation. It binds to calcineurin inhibiting its phosphatase activity which in turn reduces NFAT transcription factor activation. Carabin forms part of complexes within cells including those involving proteins like Ras which further modulates its regulatory functions. These interactions place carabin as an important protein in the context of immune system modulation and response.

Pathways

Carabin participates in T-cell receptor (TCR) signaling and calcium signaling pathways. The interaction with calcineurin links carabin to the regulation of the immune response especially in T-cell signaling and activation. It relates to proteins such as NFAT and Ras coordinating responses that control the transcription of genes important for immune cell function. This positioning in pathways highlights carabin's role in ensuring immune homeostasis.

Carabin's malfunction or dysregulation can impact immune-related conditions including autoimmune diseases and immunodeficiencies. Alterations in carabin expression or activity have connections to increased risk of autoimmune disorders where the immune system misfires against the body's own cells. Carabin's interactions with proteins like calcineurin and NFAT are important in understanding immune imbalance which could guide therapeutic strategies for such conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
See full target information TBC1D10C
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Genome research 30:155-163 PubMed31953347

2020

A regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhang,Anshun He,Bohan Chen,Jinfang Bi,Jun Chen,Dianhao Guo,Yuyang Qian,Wenbin Wang,Tengfei Shi,Zhongfang Zhao,Jiandang Shi,Woojin An,Frank Attenello,Wange Lu
View all publications
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Product promise

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