Anti-carabin antibody

Supplementary info

Activity summary

Carabin also known as TBC1D10C functions as a signaling protein involved in the regulation of T-cell activation and calcium signaling. It has a molecular mass of approximately 40 kDa. This protein is expressed across various tissues with significant expression in immune system cells such as T-cells. Carabin interacts with other proteins within cells to control processes that are vital for maintaining proper immune responses.

Biological function summary

Carabin acts as a negative regulator for the calcineurin-NFAT signaling pathway helping to control immune cell activation. It binds to calcineurin inhibiting its phosphatase activity which in turn reduces NFAT transcription factor activation. Carabin forms part of complexes within cells including those involving proteins like Ras which further modulates its regulatory functions. These interactions place carabin as an important protein in the context of immune system modulation and response.

Pathways

Carabin participates in T-cell receptor (TCR) signaling and calcium signaling pathways. The interaction with calcineurin links carabin to the regulation of the immune response especially in T-cell signaling and activation. It relates to proteins such as NFAT and Ras coordinating responses that control the transcription of genes important for immune cell function. This positioning in pathways highlights carabin's role in ensuring immune homeostasis.

Associated diseases and disorders

Carabin's malfunction or dysregulation can impact immune-related conditions including autoimmune diseases and immunodeficiencies. Alterations in carabin expression or activity have connections to increased risk of autoimmune disorders where the immune system misfires against the body's own cells. Carabin's interactions with proteins like calcineurin and NFAT are important in understanding immune imbalance which could guide therapeutic strategies for such conditions.