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AB96677

Anti-CARHSP1 antibody

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(3 Publications)

Rabbit Polyclonal CARHSP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CARHSP1 aa 1 to C-terminus.

View Alternative Names

Calcium-regulated heat-stable protein 1, Calcium-regulated heat-stable protein of 24 kDa, CRHSP-24, CARHSP1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CARHSP1 antibody (AB96677)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CARHSP1 antibody (AB96677)

Immunohistochemical analysis of CARHSP1 in paraffin embedded A549 xenograft, using ab96677 at a 1/100 dilution.

Western blot - Anti-CARHSP1 antibody (AB96677)
  • WB

Unknown

Western blot - Anti-CARHSP1 antibody (AB96677)

15% SDS Page

All lanes:

Western blot - Anti-CARHSP1 antibody (ab96677) at 1/1000 dilution

All lanes:

HepG2 whole cell lysate at 30 µg

Predicted band size: 16 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human CARHSP1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y2V2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 10% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CARHSP1 also known as Calcium-regulated Heat Stable Protein 1 is a 15 kDa protein. It plays a significant role in RNA-binding and stabilization influencing RNA metabolism. This protein is expressed in various human tissues including liver heart and muscle which suggests its importance across different biological processes. CARHSP1 has a strong affinity for specific RNA sequences which contributes to its function in post-transcriptional regulation.
Biological function summary

CARHSP1 influences cellular stress responses through its role in RNA stability. It associates with RNA-protein complexes modulating the expression of stress-responsive genes. This protein becomes particularly active under stress conditions like heat shock facilitating survival and adaptation. Its interaction with other elements of the stress granules points to its integrative role in cellular adaptability mechanisms.

Pathways

CARHSP1 participates prominently in post-transcriptional gene regulation pathways. The protein is actively involved in the stress response pathway where it stabilizes target mRNAs during cellular stress conditions. CARHSP1 interacts with proteins such as TIA1 and G3BP key players in the assembly of stress granules further assisting in the stabilization and regulation of specific mRNA transcripts.

Studies suggest that CARHSP1 has implications in certain cancer types and neurodegenerative diseases. Its overexpression or dysregulation may contribute to oncogenic processes in some cancers possibly due to its role in mRNA stabilization of proliferation-related genes. Additionally alterations in CARHSP1 function might relate to neurodegenerative diseases where aberrant stress response pathways are often observed. It connects with proteins like Hsp70 which are also involved in stress and disease response pathways further underlining its potential impact on these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).
See full target information CARHSP1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell & bioscience 15:33 PubMed40055805

2025

The RNA binding protein CARHSP1 facilitates tumor growth, metastasis and immune escape by enhancing IL-17RA mRNA stabilization in prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

YiFan Jiang,Yanan Wang,KaiHua Xue,JianBin Ma,Shan Xu,Ke Wang,Peng Guo

Nature communications 14:3122 PubMed37264009

2023

Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos E Bravo-Iñiguez,Jason R Fritz,Shilpa Shukla,Susmita Sarangi,Dane A Thompson,Seema G Amin,Tea Tsaava,Saher Chaudhry,Sara P Valentino,Hannah B Hoffman,Catherine W Imossi,Meghan E Addorisio,Sergio I Valdes-Ferrer,Sangeeta S Chavan,Lionel Blanc,Christopher J Czura,Kevin J Tracey,Jared M Huston

Cell death & disease 12:724 PubMed34290231

2021

Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Guo-Dong Zhu,Jing Yu,Zheng-Yu Sun,Yan Chen,Hong-Mei Zheng,Mei-Lan Lin,Shi Ou-Yang,Guo-Long Liu,Jie-Wen Zhang,Feng-Min Shao
View all publications
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Product promise

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