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AB2012

Anti-Caspase-10/CASP-10 antibody

5

(1 Review)

|

(4 Publications)

Rabbit Polyclonal Caspase-10/CASP-10 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CASP10 aa 500 to C-terminus.

View Alternative Names

MCH4, CASP10, Caspase-10, CASP-10, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, ICE-like apoptotic protease 4, FLICE2

2 Images
Immunocytochemistry - Anti-Caspase-10/CASP-10 antibody (AB2012)
  • ICC

Supplier Data

Immunocytochemistry - Anti-Caspase-10/CASP-10 antibody (AB2012)

Immunocytochemistry/Immunofluorescence of HeLa cells labeling Caspase-10/CASP-10 with Anti-Caspase-10/CASP-10 antibody (ab2012) at 5μg/ml.

Western blot - Anti-Caspase-10/CASP-10 antibody (AB2012)
  • WB

Unknown

Western blot - Anti-Caspase-10/CASP-10 antibody (AB2012)

All lanes:

Western blot - Anti-Caspase-10/CASP-10 antibody (ab2012) at 1/1000 dilution

Lane 1:

HeLa whole cell lysate

Lane 2:

Jurkat whole cell lysate

Lane 3:

A431 whole cell lysate

Lane 4:

K562 whole cell lysate

Lane 5:

NIH3T3 whole cell lysate

Predicted band size: 58 kDa

Observed band size: 59 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC

applications

Immunogen

Synthetic Peptide within Human CASP10 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q92851

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Ion exchange chromatography DEAE-C
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis.. Isoform C is proteolytically inactive.
See full target information CASP10
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 56: PubMed40937577

2025

CDC5L binds to ELAVL1 to inhibit pyroptosis in hepatocellular carcinoma through the Caspase 3/GSDME signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shuai Liang,Zhongcheng Zhu,Yangshuo Tang,Shuhua Zhou,Moyan Xiao,Xuejun Gong,Ke Ye

Renal failure 33:192-206 PubMed21332342

2011

Multiple caspases mediate acute renal cell apoptosis induced by bacterial cell wall components.

Applications

Unspecified application

Species

Unspecified reactive species

Marlyn P Langford,David J McGee,Kathy H Ta,Thomas B Redens,Donald E Texada

Clinical cancer research : an official journal of the American Association for Cancer Research 15:1199-209 PubMed19228726

2009

The combined therapeutic effects of bortezomib and fenretinide on neuroblastoma cells involve endoplasmic reticulum stress response.

Applications

WB

Species

Human

Gabriella Pagnan,Daniela Di Paolo,Roberta Carosio,Fabio Pastorino,Danilo Marimpietri,Chiara Brignole,Annalisa Pezzolo,Monica Loi,Luis J V Galietta,Federica Piccardi,Michele Cilli,Beatrice Nico,Domenico Ribatti,Vito Pistoia,Mirco Ponzoni

The Journal of biological chemistry 279:25149-56 PubMed15069074

2004

Caspase-mediated Cleavage of Insulin Receptor Substrate.

Applications

Unspecified application

Species

Unspecified reactive species

Kirsty A Green,Matthew J Naylor,Emma T Lowe,Pengbo Wang,Emma Marshman,Charles H Streuli
View all publications
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