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AB182657

Anti-Caspase-2 antibody

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(3 Publications)

Rabbit Polyclonal Caspase-2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CASP2 aa 1-250.

View Alternative Names

ICH1, NEDD2, CASP2, Caspase-2, CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, Protease ICH-1, NEDD-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-2 antibody (AB182657)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-2 antibody (AB182657)

Immunohistochemical analysis of paraffin-embedded human urinary bladder tissue labeling Caspase 2 using ab182657 at 1/100 dilution. The right panel is treated with the fusion protein.

Western blot - Anti-Caspase-2 antibody (AB182657)
  • WB

Supplier Data

Western blot - Anti-Caspase-2 antibody (AB182657)

10% SDS PAGE

All lanes:

Western blot - Anti-Caspase-2 antibody (ab182657) at 1/950 dilution

Lane 1:

Human fetal kidney lysate at 30 µg

Lane 2:

Human fetal lung lysate at 30 µg

Secondary

All lanes:

Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution

Predicted band size: 51 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CASP2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P42575

Specificity

The antibody detects endogenous level of total Caspase 2 protein.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/300", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed : 11156409, PubMed : 15073321, PubMed : 8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed : 15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed : 15073321).. Isoform 1. Acts as a positive regulator of apoptosis.. Isoform 2. Acts as a negative regulator of apoptosis.. Isoform 3. May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death.
See full target information CASP2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell metabolism 34:1548-1560.e6 PubMed36041455

2022

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Ju Youn Kim,Lily Q Wang,Valentina C Sladky,Tae Gyu Oh,Junlai Liu,Kaitlyn Trinh,Felix Eichin,Michael Downes,Mojgan Hosseini,Etienne D Jacotot,Ronald M Evans,Andreas Villunger,Michael Karin

Cancer management and research 12:5201-5212 PubMed32636681

2020

microRNA-582 Potentiates Liver and Lung Metastasis of Gastric Carcinoma Cells Through the FOXO3-Mediated PI3K/Akt/Snail Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Tianyu Xie,Di Wu,Shuo Li,Xiongguang Li,Lipeng Wang,Yixun Lu,Qiying Song,Xuehong Sun,Xinxin Wang

Experimental and therapeutic medicine 19:603-610 PubMed31897103

2020

Upregulated miRNA-182-5p expression in tumor tissue and peripheral blood samples from patients with non-small cell lung cancer is associated with downregulated Caspase 2 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Yang,Ye Dou,Zhuxin Sui,Hui Cheng,Xia Liu,Qinglu Wang,Peifu Gao,Yin'e Qu,Ming Xu
View all publications
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