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AB244412

Anti-CASZ1 antibody

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Rabbit Polyclonal CASZ1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CASZ1 aa 150-300.

View Alternative Names

CST, SRG, ZNF693, CASZ1, Zinc finger protein castor homolog 1, Castor-related protein, Putative survival-related protein, Zinc finger protein 693

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CASZ1 antibody (AB244412)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CASZ1 antibody (AB244412)

Paraffin-embedded human skin tissue stained for CASZ1 using ab244412 at 1/50 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-CASZ1 antibody (AB244412)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CASZ1 antibody (AB244412)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for CASZ1 (green) using ab244412 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CASZ1 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

Q86V15

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CASZ1 also known as Castor zinc finger 1 is a transcription factor with a molecular mass around 131 kDa. It contains zinc finger motifs which allow it to bind DNA and regulate gene expression. This protein is ubiquitously expressed prominently found during development in tissues like the heart brain and vascular systems. CASZ1 plays an important role in cellular processes through its regulatory actions.
Biological function summary

This transcription factor influences cardiovascular development and neural differentiation. It is part of no known complex but interacts with other proteins for its function. CASZ1 regulates gene networks that are necessary for proper cell cycle progression and differentiation. Its presence ensures cells develop with the right timing and destinations especially in tissues demanding precise regulation.

Pathways

CASZ1 integrates into significant developmental pathways. It participates in the Notch signaling pathway important for vascular development and heart formation. Through these pathways CASZ1 interacts with other proteins such as Notch receptors and Delta ligands. This linkage helps synchronize gene expression for tissue-specific development.

CASZ1 links to congenital heart disease and neuroblastoma. Mutations or deregulation in CASZ1 expression have been associated with improper heart formation in congenital defects. In neuroblastoma its dysregulation alters cellular differentiation. CASZ1 interacts with proteins like MYCN in neuroblastoma relating to the malignancy's progression. Understanding CASZ1's roles could reveal therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional activator (PubMed : 23639441, PubMed : 27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed : 23639441).
See full target information CASZ1
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Product promise

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