Anti-Cathelicidin/CLP antibody [EPR20469]

Target data

Antimicrobial protein that is an integral component of the innate immune system (PubMed : 14978112, PubMed : 16637646, PubMed : 18818205, PubMed : 22879591, PubMed : 9736536). Binds to bacterial lipopolysaccharides (LPS) (PubMed : 16637646, PubMed : 18818205). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed : 22879591). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (PubMed : 14978112). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) (PubMed : 9736536).. Antibacterial peptide LL-37. Antimicrobial peptide that is an integral component of the innate immune system (PubMed : 10417311, PubMed : 15778390, PubMed : 16637646, PubMed : 18818205, PubMed : 22879591, PubMed : 32753597, PubMed : 33060695, PubMed : 34708076, PubMed : 8681941, PubMed : 9736536). Binds to bacterial lipopolysaccharides (LPS) (PubMed : 10417311, PubMed : 16637646, PubMed : 18818205, PubMed : 33060695, PubMed : 9736536). Causes membrane permeabilization by forming transmembrane pores (in vitro) (PubMed : 22879591, PubMed : 32753597, PubMed : 33060695). Causes lysis of E.coli (PubMed : 10417311). Exhibits antimicrobial activity against Gram-negative bacteria such as P.aeruginosa, S.typhimurium, E.aerogenes, E.coli and P.syringae, Gram-positive bacteria such as L.monocytogenes, S.epidermidis, S.pyogenes and S.aureus, as well as vancomycin-resistant enterococci (in vitro) (PubMed : 10417311, PubMed : 32753597, PubMed : 8681941, PubMed : 9736536). Exhibits antimicrobial activity against methicillin-resistant S.aureus, P.mirabilis, and C.albicans in low-salt media, but not in media containing 100 mM NaCl (in vitro) (PubMed : 9736536). Forms chiral supramolecular assemblies with quinolone signal (PQS) molecules of P.aeruginosa, which may lead to interference of bacterial quorum signaling and perturbance of bacterial biofilm formation (PubMed : 34708076). May form supramolecular fiber-like assemblies on bacterial membranes (PubMed : 29133814). Induces cytokine and chemokine production as well as TNF/TNFA and CSF2/GMCSF production in normal human keratinocytes (PubMed : 15778390). Exhibits hemolytic activity against red blood cells (PubMed : 10417311).. Antibacterial peptide FALL-39. Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).. Antibacterial peptide KR-20. Acts synergistically with peptides KS-30 and KR-31, killing bacteria such as S.aureus, E.coli and C.albicans at lower concentrations when present together, and maintains activity at increased salt condition (PubMed : 14978112). Does not have the ability to stimulate CXCL8/IL8 release from keratinocytes (PubMed : 14978112).. Antibacterial peptide LL-23. Poorly active (MIC > 150 uM) against E.coli strain K12 (PubMed : 14978112). Is able to induce the pro-inflammatory cytokine TNF/TNFA or the chemokine CCL2/MCP1 (PubMed : 14978112).. Antibacterial peptide LL-29. Moderately antibacterial.. Antibacterial peptide KS-30. Moderately antibacterial (PubMed : 14978112). Acts synergistically with peptides KR-20 and KR-31, killing bacteria such as S.aureus, E.coli and C.albicans at lower concentrations when present together, and maintain activity at increased salt condition (PubMed : 14978112). Does not have the ability to stimulate CXCL8/IL8 release from keratinocytes (PubMed : 14978112).. Antibacterial peptide RK-31. Acts synergistically with peptides KS-30 and KR-31, killing bacteria such as S.aureus, E.coli and C.albicans at lower concentrations when present together, and maintain activity at increased salt condition (PubMed : 14978112). Does not have the ability to stimulate CXCL8/IL8 release from keratinocytes (PubMed : 14978112).. Antibacterial peptide FF-33. Inhibits the growth of E.coli and B.megaterium and exhibits hemolytic activity against human red blood cells.