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AB89414

Anti-Cathepsin E antibody

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(1 Publication)

Mouse Polyclonal Cathepsin E antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Cathepsin E aa 1 to C-terminus.

View Alternative Names

Cathepsin E, CTSE

2 Images
Western blot - Anti-Cathepsin E antibody (AB89414)
  • WB

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Western blot - Anti-Cathepsin E antibody (AB89414)

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Western blot - Anti-Cathepsin E antibody (ab89414) at 1 µg/mL

Lane 1:

Cathepsin E transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected lysate at 25 µg

Predicted band size: 43 kDa

Observed band size: 43 kDa

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Western blot - Anti-Cathepsin E antibody (AB89414)
  • WB

Unknown

Western blot - Anti-Cathepsin E antibody (AB89414)

All lanes:

Western blot - Anti-Cathepsin E antibody (ab89414) at 1 µg/mL

All lanes:

Human stomach lysate at 50 µg

Predicted band size: 43 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human Cathepsin E aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P14091

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cathepsin E also known as CATE is an aspartic protease with a molecular mass of approximately 40 kDa. It functions within the cell to perform endopeptidase activity meaning it cleaves peptide bonds within proteins. Cathepsin E shows expression in the gastric mucosa and is prevalent in immune-related tissues such as the spleen and thymus. This enzyme operates optimally at acidic pH levels specializing in the breakdown of proteins in lysosomes.
Biological function summary

Cathepsin E plays a role in protein degradation and processing within lysosomal compartments. It associates with lysosomal and endosomal pathways participating actively in immune response regulation. Cathepsin E does not form part of a larger complex; however its activity can influence the function of other immune-related proteins by modifying antigen presentation.

Pathways

Cathepsin E engages with the major histocompatibility complex (MHC) class II pathway. This involvement assists in the processing of antigenic peptides for presentation to CD4+ T-cells connecting Cathepsin E to adaptive immune responses. Additionally it interacts with proteins such as HLA-DM which modulates the peptide loading on MHC class II molecules during immune surveillance.

Researchers link Cathepsin E to gastric cancer and Alzheimer's disease. In gastric cancer Cathepsin E overexpression can alter tumor microenvironments impacting disease progression. Furthermore in Alzheimer's disease Cathepsin E's activity correlates with amyloid precursor protein (APP) metabolism which can influence the accumulation of amyloid-beta plaques a hallmark of the disease process.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
See full target information Cathepsin E
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International neurourology journal 29:S44-S52 PubMed40776597

2025

High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Jong-Hwa Won,Ying-Ying Xiang,Kyung-Wan Baek,Min-Jeong Kang,Ji-Seok Kim
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Product promise

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