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AB124656

Anti-Cathepsin V antibody

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(4 Publications )

Rabbit Polyclonal Cathepsin V antibody. Suitable for IHC-P, WB and reacts with Human, African green monkey samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CTSV.

View Alternative Names

CATL2, CTSL2, CTSU, UNQ268/PRO305, CTSV, Cathepsin L2, Cathepsin U, Cathepsin V

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin V antibody (AB124656)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin V antibody (AB124656)

ab124656, at 1/500 dilution, staining Cathepsin V in Formalin-Fixed, Paraffin-Embedded Human breast tissue by Immunohistochemistry.

Western blot - Anti-Cathepsin V antibody (AB124656)
  • WB

Unknown

Western blot - Anti-Cathepsin V antibody (AB124656)

All lanes:

Western blot - Anti-Cathepsin V antibody (ab124656) at 1/500 dilution

Lane 1:

293 cell extracts, treated with etoposide 25uM 1h

Lane 2:

COS cell extracts, treated with etoposide 25uM 1h

Lane 3:

293 cell extracts, treated with etoposide 25uM 1h with synthesized peptide

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, African green monkey

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human CTSV. The exact immunogen used to generate this antibody is proprietary information.

O60911

Specificity

ab124656 detects endogenous levels of fragment of activated CATL2 resulting from cleavage adjacent to Leu114.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "African green monkey": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cathepsin V also known as cathepsin L2 is a cysteine protease enzyme involved in protein degradation. This enzyme has a molecular mass of approximately 37 kDa. Cathepsin V predominantly resides in lysosomes cellular organelles known for breaking down waste materials. It is highly expressed in thymus cornea and testis suggesting its significant role in tissues that require extensive protein turnover.
Biological function summary

Cathepsin V plays essential roles in the degradation of intracellular proteins by cleaving peptide bonds. Although not part of a complex its activity helps regulate immune responses and processing of antigens keeping cellular functions normal. Cathepsin V shows high proteolytic activity which is suited for tissues where high protein breakdown and recycling are necessary.

Pathways

Cathepsin V participates in pathways linked to protein catabolism and immune system regulation. It takes part in the antigen processing and presentation pathway contributing to immune surveillance. Within these pathways its activity can interact with other proteases like cathepsin S showing functional redundancy or specificity depending on tissue type and conditions.

Cathepsin V is associated with cancer and autoimmune diseases. In some cancers its overexpression may facilitate tumor progression by degrading extracellular matrix components aiding metastasis. This upregulation can involve interaction with proteins such as cathepsin B which also modifies extracellular environments. In autoimmune disorders altered regulation of cathepsin V affects antigen processing possibly leading to abnormal immune responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cysteine protease. May have an important role in corneal physiology.
See full target information CTSV
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of general medicine 17:4867-4881 PubMed39465186

2024

The Prognostic Significance of CTSV Expression in Patients with Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yuping He,Minghao Xu,Chenhao Zhou,Qiongzhu Dong,Zhiqiu Hu,Ning Ren

BMC biology 20:67 PubMed35296311

2022

Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.

Applications

Unspecified application

Species

Unspecified reactive species

Morag A Lewis,Neil J Ingham,Jing Chen,Selina Pearson,Francesca Di Domenico,Sohinder Rekhi,Rochelle Allen,Matthew Drake,Annelore Willaert,Victoria Rook,Johanna Pass,Thomas Keane,David J Adams,Abigail S Tucker,Jacqueline K White,Karen P Steel

Biochimica et biophysica acta. General subjects 1864:129544 PubMed32007579

2020

Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Preety Panwar,Tobias Hedtke,Andrea Heinz,Pierre-Marie Andrault,Wolfgang Hoehenwarter,David J Granville,Christian E H Schmelzer,Dieter Brömme

Gynecologic and obstetric investigation 84:396-406 PubMed30759440

2019

Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders.

Applications

Unspecified application

Species

Unspecified reactive species

Satoshi Matsukawa,Seiji Sumigama,Tomomi Kotani,Jingwen Wang,Rika Miki,Yoshinori Moriyama,Tomoko Nakano,Yukio Mano,Hiroyuki Tsuda,Koji Tamakoshi,Fumitaka Kikkawa
View all publications
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Product promise

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