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AB197924

Anti-CATSPER3 antibody

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(1 Publication)

Rabbit Polyclonal CATSPER3 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Fusion protein corresponding to CATSPER3, fused to CATSPER3.

View Alternative Names

Cation channel sperm-associated protein 3, CatSper3, Ca(v)-like protein, One-repeat calcium channel-like protein, CATSPER3

1 Images
Western blot - Anti-CATSPER3 antibody (AB197924)
  • WB

Supplier Data

Western blot - Anti-CATSPER3 antibody (AB197924)

All lanes:

Western blot - Anti-CATSPER3 antibody (ab197924) at 1/350 dilution

All lanes:

Mouse testis lysate at 40 µg

Predicted band size: 46 kDa

false

Exposure time: 2min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Fusion protein corresponding to CATSPER3, fused to CATSPER3. The exact immunogen used to generate this antibody is proprietary information.

Q86XQ3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CATSPER3 also known as Cation Channel Sperm-Associated Protein 3 functions primarily as a calcium selective ion channel. This protein with a molecular weight of approximately 85 kDa forms part of the CATSPER channel complex located on the flagellar membrane of sperm cells. Expression of CATSPER3 occurs mainly in the testis. The channel plays a critical role in mediating calcium influx necessary for sperm motility and fertilization capabilities.
Biological function summary

CATSPER3 contributes significantly to sperm function. It forms a complex with other CATSPER proteins — CATSPER1 CATSPER2 and CATSPER4 — that combine to create a functional ion channel. This channel regulates calcium entry in response to triggers such as progesterone important for hyperactivation of sperm cells an enhanced motility state that facilitates penetration through the egg's zona pellucida. Disruption in any part of this complex impairs sperm function and can affect fertility.

Pathways

CATSPER3 operates within the pathway controlling sperm motility often influenced by the CatSper signaling pathway. This pathway governs calcium ion entry a pivotal event for initiating and sustaining sperm hyperactivated motility. CATSPER3 interacts closely with accessory proteins including CATSPERβ and CATSPERG supporting proper localization and functioning of the CATSPER ion channel within the sperm tail.

CATSPER3 has associations with male infertility particularly in cases related to asthenozoospermia a condition marked by reduced sperm motility. The protein interacts with other CATSPER proteins and mutations in CATSPER1 or CATSPER2 are also linked to similar fertility issues. The importance of CATSPER3 in regulating sperm motility stresses its role in reproductive health with dysfunctions potentially leading to subfertility or infertility in males.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
See full target information CATSPER3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 11:1136537 PubMed38020915

2023

CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm.

Applications

Unspecified application

Species

Unspecified reactive species

Taiga Kijima,Daisuke Kurokawa,Yasunori Sasakura,Michio Ogasawara,Satoe Aratake,Kaoru Yoshida,Manabu Yoshida
View all publications
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