AB38468

Anti-Caveolin-1 (phospho Y14) antibody - Caveolae Marker

Name: Anti-Caveolin-1 (phospho Y14) antibody - Caveolae Marker (ab38468) | Abcam
Brand: Abcam Limited
SKU: AB38468
Price: 400 USD
Availability: InStock
Rating: 4 (2 reviews)

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What is this?

(2 Reviews)

(2 Publications)

Rabbit Polyclonal Caveolin-1 phospho Y14 antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CAV1 phospho Y14.

View Alternative Names

CAV, CAV1, Caveolin-1

1 Images

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Western blot - Anti-Caveolin-1 (phospho Y14) antibody - Caveolae Marker (AB38468)

Lanes 1 - 2:

Western blot - Anti-Caveolin-1 (phospho Y14) antibody - Caveolae Marker (ab38468)

Lanes 3 - 4:

Western blot - Anti-Caveolin-1 (phospho Y14) antibody - Caveolae Marker (ab38468) at 1/500 dilution

Lane 1:

NIH 3T3 cell extract

Lane 2:

NIH 3T3 cell extract. Pre-incubated with synthesized peptide

Lane 3:

NIH 3T3 cell extract.

Lane 4:

NIH 3T3 cell extract. Treated with H2O2.

Predicted band size: 20 kDa

Observed band size: 20 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

Synthetic Peptide within Human CAV1 phospho Y14. The exact immunogen used to generate this antibody is proprietary information.

Q03135

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Caveolin-1 also known as Cav-1 is an integral membrane protein with a molecular weight of approximately 22 kDa. It functions mechanically as a scaffolding protein in caveolae which are tiny invaginations in the plasma membrane of many cell types. These structures are particularly abundant in adipocytes endothelial cells and muscle cells. Caveolin-1 anchors itself to the cell membrane and plays a role in organizing and concentrating certain signaling molecules.

Biological function summary

Caveolae provide a platform for various signaling pathways and involve caveolin-1 as a major component. Caveolin-1 interacts with multiple signaling molecules such as G-protein coupled receptors and Src family kinases to modulate signal transduction. This protein forms part of a larger caveolar complex contributing to cellular processes including endocytosis and lipid regulation. Its presence as a marker in caveolae highlights its significance in cellular functions.

Pathways

Caveolin-1 influences the insulin signaling and nitric oxide (NO) signaling pathways. In the insulin signaling pathway caveolin-1 interacts with insulin receptors to modulate glucose uptake. It also associates with eNOS (endothelial nitric oxide synthase) in the NO signaling pathway impacting vascular function. These relationships highlight its role in cellular communication and regulatory mechanisms within the human body.

Caveolin-1 is involved in cancer and cardiovascular diseases. In cancer altered expression of caveolin-1 contributes to tumor progression while in cardiovascular diseases it affects endothelial function through its interaction with eNOS. The connection of caveolin-1 to proteins like insulin receptors and eNOS reveals its critical influence in these conditions providing potential targets for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May act as a scaffolding protein within caveolar membranes (PubMed : 11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed : 19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed : 17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed : 25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity).

See full target information CAV1 phospho Y14

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Science progress 108:368504251336287 PubMed40296549

2025

Suppression of SRC protein kinase activity alleviates the severity of aganglionosis by impairing CAV1/FLNA expression.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaogang Xu,Yanqing Liu,Menglong Lan,Fei Liu,Huimin Xia,Jixiao Zeng

Oncotarget 7:82538-82553 PubMed27769065

2016

The serum protein profile of early parity which induces protection against breast cancer.

Applications

Species

Human

Christina Gutierrez Bracamontes,Rebecca Lopez-Valdez,Ramadevi Subramani,Arunkumar Arumugam,Sushmita Nandy,Venkatesh Rajamanickam,Vignesh Ravichandran,Rajkumar Lakshmanaswamy

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Caveolin-1 (phospho Y14) antibody - Caveolae Marker

Western blot - Anti-Caveolin-1 (phospho Y14) antibody - Caveolae Marker (AB38468)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise