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AB237050

Anti-CBWD2 antibody

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(1 Publication)

Rabbit Polyclonal CBWD2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNG1B aa 50 to C-terminus.

View Alternative Names

CBWD2, ZNG1B, Zinc-regulated GTPase metalloprotein activator 1B, Cobalamin synthase W domain-containing protein 2, COBW domain-containing protein 2

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-CBWD2 antibody (AB237050)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CBWD2 antibody (AB237050)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for CBWD2 (green) using ab237050 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CBWD2 antibody (AB237050)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CBWD2 antibody (AB237050)

Paraffin-embedded human prostate cancer tissue stained for CBWD2 using ab237050 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CBWD2 antibody (AB237050)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CBWD2 antibody (AB237050)

Paraffin-embedded human tonsil tissue stained for CBWD2 using ab237050 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ZNG1B aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IUF1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CBWD2 also known as Cobalt Chelatase D Homolog 2 is a human protein weighing approximately 36 kDa. Mechanically CBWD2 functions in metal ion binding particularly with cobalt ions. This protein locates itself in the cytosol and is expressed across various tissues although specific expression levels can vary. CBWD2 participates in metal homeostasis and may interact with other proteins involved in metal processing.
Biological function summary

The protein CBWD2 plays a role in maintaining metal ion balance within cells important for cellular processes that involve metal cofactors. It is thought to be part of a larger protein complex that regulates metal ion transport and storage. This complex aids in protecting cells from metal toxicity and ensures proper functioning of enzymatic reactions that need metal ions as cofactors.

Pathways

CBWD2 participates in metal ion transport and detoxification pathways. It interacts with proteins involved in the transport of metal ions across cellular membranes. For instance CBWD2 shows functional relationships with metallothioneins known for binding heavy metals and with proteins in the cation transport pathway. This is integral for balancing metal ion distribution and mitigating potential metal-induced oxidative stress.

CBWD2 may have relevance to conditions such as metal ion imbalance and neurodegenerative disorders that involve metal deposition like Alzheimer's disease. Alterations in CBWD2 expression or function could disrupt metal homeostasis contributing to the pathology of these diseases. Moreover its interactions with metallothioneins and proteins regulating metal transport suggest that CBWD2 might be significant in conditions related to metal ion dysregulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1B to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1.
See full target information ZNG1B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Immunology 172:588-599 PubMed38634546

2024

Oligodeoxynucleotides containing CpG motifs (CpG-ODN) restores immune regulatory functions of airway macrophages of patients with asthma.

Applications

Unspecified application

Species

Unspecified reactive species

Huanping Zhang,Lihuan Wang,Aizhi Zhang,Xiangyu Wang,Yun Liao,Xiaoxue Chen,Xuejie Xu,Litao Yang,Yu Liu,Aifa Tang,Pingchang Yang
View all publications
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Product promise

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