Anti-Cbx8 antibody [EPR23800-14]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cbx8 also known as Chromobox protein homolog 8 is part of the Polycomb group proteins with a molecular mass of approximately 50 kDa. Cbx8 functions as a transcriptional regulator by binding to histones and repressive chromatin states. It has a broad expression including in embryonic stem cells and various adult tissues. Its involvement extends to chromatin modification and impacts gene expression regulation making it significant in controlling cellular identity and differentiation.

Biological function summary

Cbx8 contributes to the regulation of gene silencing within the Polycomb Repressive Complex 1 (PRC1). It plays an important role in maintaining cellular memory by ensuring heritable transcriptional repression of target genes. Cbx8's involvement in histone modification particularly histone H3 lysine 27 trimethylation (H3K27me3) is a part of its mechanism to regulate gene expression. This regulation affects key developmental processes and signals cellular differentiation pathways critical for tissue development and maintenance.

Pathways

Cbx8 engages in the Polycomb pathway where it interacts with other PRC1 proteins playing a role in chromatin compaction and silencing of developmental genes. It associates with pathways involved in cell cycle regulation and differentiation linking to essential proteins like RING1 and BMI1. These interactions enable Cbx8 to influence the transcriptional repression necessary for proper execution of developmental programs and cellular response to external signals.

Associated diseases and disorders

Cbx8 has affiliations with cancer and developmental disorders due to its role in gene silencing. Abnormal Cbx8 activity may lead to disruptions in normal cell cycle controls contributing to oncogenesis with other PRC1 members like BMI1. It also connects to certain developmental syndromes where polycomb dysfunction impacts normal tissue development indicating its broader significance in maintaining cellular homeostasis and genomic stability.