Anti-CC137 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The CC137 protein also known as C-C motif chemokine ligand 13 (CCL13) functions mechanically as a cytokine involved in immune system signaling. This protein has a molecular mass of approximately 10 kDa. It is mainly expressed in immune cells including macrophages monocytes and lymphocytes. The CC137 protein can induce chemotaxis directing the movement of immune cells to sites of inflammation and infection.

Biological function summary

CC137 is essential for modulating immune responses and is part of the chemokine family which regulates the migration of leukocytes. CC137 can form part of a larger cytokine signaling complex enhancing the communication between immune cells. It is involved in the regulation of inflammatory responses by activating specific receptors on the surface of target cells which leads to the activation of intracellular signaling pathways.

Pathways

CC137 participates in the chemokine signaling pathway and the JAK-STAT signaling pathway. It plays a role in the recruitment and activation of immune cells through interactions with chemokine receptors like CCR2 and CCR3. These pathways are important for movements and activation of various immune cell types linking CC137 to proteins such as JAK2 and STAT3 which are integral to signal transduction processes.

Associated diseases and disorders

CC137 has been implicated in inflammatory diseases and allergic responses. It is connected to asthma through its role in promoting eosinophil movement and activation. Additionally CC137 is linked to rheumatoid arthritis where aberrant expression contributes to chronic inflammation within joints. In these diseases CC137 can interact with TNF-alpha a critical cytokine related to inflammation and immune responses.