AB91585
Rabbit Polyclonal CCDC47 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CCDC47.
3 Images
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-CCDC47 antibody (AB91585)
Immunofluorescence of CDCC47 in mouse heart tissue with ab91585 at 20 ug/mL.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC47 antibody (AB91585)
Immunohistochemistry of mouse heart tissue with ab91585 at 5 μg/mL.
- WB
Unknown
Western blot - Anti-CCDC47 antibody (AB91585)
Lane 1:
Western blot - Anti-CCDC47 antibody (ab91585) at 1 µg/mL
Lane 2:
Western blot - Anti-CCDC47 antibody (ab91585) at 2 µg/mL
All lanes:
Mouse heart tissue lysate at 15 µg
Predicted band size: 56 kDa
false
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Reactivity data
{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
Properties and storage information
Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Product protocols
For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed : 32814900, PubMed : 32820719, PubMed : 36261522). The MPT complex takes over after the SEC61 complex : following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed : 36261522). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity). Involved in the regulation of calcium ion homeostasis in the ER (PubMed : 30401460). Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (PubMed : 25009997). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity).
Alternative Names
GK001, MSTP041, PSEC0077, CCDC47, PAT complex subunit CCDC47, Calumin, Coiled-coil domain-containing protein 47
Publications (1)
Recent publications for all applications. Explore the full listand refine your search
Scientific reports 13:10401 PubMed37369713
2023
Shotgun proteomics identification of proteins expressed in the Descemet's membrane of patients with Fuchs endothelial corneal dystrophy.
Applications
Unspecified application
Species
Unspecified reactive species
Tatsuya Nakagawa,Naoki Okumura,Masaya Ikegawa,Yumiko Toyama,Takashi Nirasawa,Frederic Mascarelli,Hanielle Vaitinadapoule,Ines Aouimeur,Zhiguo He,Philippe Gain,Gilles Thuret,Noriko Koizumi
Product promise
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